Sandra P. Chang
Title Professor
Faculty Rank
Degree Ph.D.
Institution University of Hawaii
Department Department of Tropical Medicine, Medical Microbiology and Pharmacology
Clusters HIV/AIDS
Infectious and Immunological Diseases
Neurological Disorders and Mental Health
Address
John A. Burns School of Medicine
651 Ilalo Street, Rm. 320H
City Honolulu
State HI
Postal Code 96813
Telephone 808 692-1607
Fax
Email
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Other Positions

Title Professor
Institution John A Burns School of Medicine, University of Hawaii at Manoa
Department Tropical Medicine, Medical Microbiology & Pharmacology

Narrative

Dr. Chang is a Professor of Tropical Medicine and Chair of the Tropical Medicine Graduate Program. She joined the department in 1986 as a researcher in the malaria vaccine development program and currently is principal investigator on research projects on malaria immunology and vaccine development and metabolomic analysis of P. falciparum-infected erythrocytes. Her areas of interest in malaria vaccine development include mechanisms of immunity to P. falciparum blood stages, development of adjuvants for blood stage malaria vaccines, and requirements for effective germinal center formation and memory B cell development for malaria vaccines. Malaria metabolomics projects include the application of mass spectrometry to the discovery of new metabolic pathways that may be exploited for malaria drug development. Dr. Chang teaches graduate courses in infectious disease immunology and immunopathogenesis and lectures on topics related to immunology and vaccination for graduate and medical students.

In addition to her academic role, Dr. Chang serves as a liaison for the RTRN Research Coordinating Center. She assists in the co-ordination of the HIV/AIDS, Infectious and Immunological Diseases, and Neurological and Mental Health Disease Research Clusters and the Mentoring and Professional Development Key Function Leaders Group.

Publications

1. Chang SP, Chun M, Guerrero A, Harris C, Kaholokula JK, Mau ML, Nakamura K, Thompson K, Zalud I. Medical School Hotline: School of Medicine Departments - Year in Review 2017, Part 2. Hawaii J Med Public Health. 2018 Feb; 77(2):35-37.
  View in: PubMed (29435389)
 
2. Sana TR, Gordon DB, Fischer SM, Tichy SE, Kitagawa N, Lai C, Gosnell WL, Chang SP. Global mass spectrometry based metabolomics profiling of erythrocytes infected with Plasmodium falciparum. PLoS One. 2013; 8(4):e60840.
  View in: PubMed (23593322)
 
3. Lau OS, Ng DW, Chan WW, Chang SP, Sun SS. Production of the 42-kDa fragment of Plasmodium falciparum merozoite surface protein 1, a leading malaria vaccine antigen, in Arabidopsis thaliana seeds. Plant Biotechnol J. 2010 Dec; 8(9):994-1004.
  View in: PubMed (20444208)
 
4. Chang SP, Kayatani AK, Terrientes ZI, Herrera S, Leke RG, Taylor DW. Shift in epitope dominance of IgM and IgG responses to Plasmodium falciparum MSP1 block 4. Malar J. 2010 Jan 13; 9:14.
  View in: PubMed (20070906)
 
5. Reed ZH, Kieny MP, Engers H, Friede M, Chang S, Longacre S, Malhotra P, Pan W, Long C. Comparison of immunogenicity of five MSP1-based malaria vaccine candidate antigens in rabbits. Vaccine. 2009 Mar 04; 27(10):1651-60.
  View in: PubMed (19038302)
 
6. Terrientes ZI, Vergara J, Kramer K, Herrera S, Chang SP. Restricted genetic diversity of Plasmodium falciparum major merozoite surface protein 1 in isolates from Colombia. Am J Trop Med Hyg. 2005 Nov; 73(5 Suppl):55-61.
  View in: PubMed (16291768)
 
7. Yoshida S, Kobayashi T, Matsuoka H, Seki C, Gosnell WL, Chang SP, Ishii A. T-cell activation and cytokine production via a bispecific single-chain antibody fragment targeted to blood-stage malaria parasites. Blood. 2003 Mar 15; 101(6):2300-6.
  View in: PubMed (12411309)
 
8. Locher CP, Tam LQ, Chang SP, McBride JS, Siddiqui WA. Plasmodium falciparum: gp195 tripeptide repeat-specific monoclonal antibody inhibits parasite growth in vitro. Exp Parasitol. 1996 Oct; 84(1):74-83.
  View in: PubMed (8888734)
 
9. Hui GS, Hashimoto AC, Nikaido CM, Choi J, Chang SP. Induction of antibodies to the Plasmodium falciparum merozoite surface protein-1 (MSP1) by cross-priming with heterologous MSP1s. J Immunol. 1994 Aug 01; 153(3):1195-201.
  View in: PubMed (8027549)
 
10. Chang SP, Nikaido CM, Hashimoto AC, Hashiro CQ, Yokota BT, Hui GS. Regulation of antibody specificity to Plasmodium falciparum merozoite surface protein-1 by adjuvant and MHC haplotype. J Immunol. 1994 Apr 01; 152(7):3483-90.
  View in: PubMed (8144929)
 
11. Chang SP. Expression systems that best mimic native structure: which ones to try first and why. Am J Trop Med Hyg. 1994; 50(4 Suppl):11-9.
  View in: PubMed (7513505)
 
12. Hui GS, Hashiro C, Nikaido C, Case SE, Hashimoto A, Gibson H, Barr PJ, Chang SP. Immunological cross-reactivity of the C-terminal 42-kilodalton fragment of Plasmodium falciparum merozoite surface protein 1 expressed in baculovirus. Infect Immun. 1993 Aug; 61(8):3403-11.
  View in: PubMed (7687586)
 
13. Hui GS, Chang SP. Plasmodium falciparum: induction of biologically active antibodies to gp195 is dependent on the choice of adjuvants. Exp Parasitol. 1992 Aug; 75(1):155-7.
  View in: PubMed (1639161)
 
14. Chang SP, Gibson HL, Lee-Ng CT, Barr PJ, Hui GS. A carboxyl-terminal fragment of Plasmodium falciparum gp195 expressed by a recombinant baculovirus induces antibodies that completely inhibit parasite growth. J Immunol. 1992 Jul 15; 149(2):548-55.
  View in: PubMed (1624802)
 
15. Hui GS, Hashimoto A, Chang SP. Roles of conserved and allelic regions of the major merozoite surface protein (gp195) in immunity against Plasmodium falciparum. Infect Immun. 1992 Apr; 60(4):1422-33.
  View in: PubMed (1548068)
 
16. Hui GS, Chang SP, Gibson H, Hashimoto A, Hashiro C, Barr PJ, Kotani S. Influence of adjuvants on the antibody specificity to the Plasmodium falciparum major merozoite surface protein, gp195. J Immunol. 1991 Dec 01; 147(11):3935-41.
  View in: PubMed (1940375)
 
17. Hui GS, Tam LQ, Chang SP, Case SE, Hashiro C, Siddiqui WA, Shiba T, Kusumoto S, Kotani S. Synthetic low-toxicity muramyl dipeptide and monophosphoryl lipid A replace Freund complete adjuvant in inducing growth-inhibitory antibodies to the Plasmodium falciparum major merozoite surface protein, gp195. Infect Immun. 1991 May; 59(5):1585-91.
  View in: PubMed (2019429)
 
18. Chang SP, Hui GS, Kato A, Siddiqui WA. Generalized immunological recognition of the major merozoite surface antigen (gp195) of Plasmodium falciparum. Proc Natl Acad Sci U S A. 1989 Aug; 86(16):6343-7.
  View in: PubMed (2668963)
 
19. Chang SP, Kramer KJ, Yamaga KM, Kato A, Case SE, Siddiqui WA. Plasmodium falciparum: gene structure and hydropathy profile of the major merozoite surface antigen (gp195) of the Uganda-Palo Alto isolate. Exp Parasitol. 1988 Oct; 67(1):1-11.
  View in: PubMed (3049134)