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Sandra P. Chang, PhD

TitleGraduate Program Chair
Faculty RankProfessor
InstitutionUniversity of Hawaii
DepartmentTropical Medicine, Medical Microbiology and Pharmacology
AddressJohn A. Burns School of Medicine
University of Hawaii at Manoa
651 Ilalo Street
Honolulu HI 96813
Phone8086921607
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    Other Positions
    TitleProfessor
    InstitutionJohn A Burns School of Medicine, University of Hawaii
    DepartmentTropical Medicine, Medical Microbiology & Pharmacology


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    Dr. Chang is a Professor of Tropical Medicine and Chair of the Tropical Medicine Graduate Program. She joined the department in 1986 as a researcher in the malaria vaccine development program and currently is principal investigator on research projects on malaria immunology and vaccine development and metabolomic analysis of P. falciparum-infected erythrocytes. Her areas of interest in malaria vaccine development include mechanisms of immunity to P. falciparum blood stages, development of adjuvants for blood stage malaria vaccines, and requirements for effective germinal center formation and memory B cell development for malaria vaccines. Malaria metabolomics projects include the application of mass spectrometry to the discovery of new metabolic pathways that may be exploited for malaria drug development. Dr. Chang teaches graduate courses in infectious disease immunology and immunopathogenesis and lectures on topics related to immunology and vaccination for graduate and medical students.

    In addition to her academic role, Dr. Chang serves as a liaison for the RTRN Research Coordinating Center. She assists in the co-ordination of the HIV/AIDS, Infectious and Immunological Diseases, and Neurological and Mental Health Disease Research Clusters and the Mentoring and Professional Development Key Function Leaders Group.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dean LS, Devendra G, Jiyarom B, Subia N, Tallquist MD, Nerurkar VR, Chang SP, Chow DC, Shikuma CM, Park J. Corrigendum: Phenotypic alteration of low-density granulocytes in people with pulmonary post-acute sequelae of SARS-CoV-2 infection. Front Immunol. 2023; 14:1209624. PMID: 37187732.
      Citations:    Fields:    
    2. Dean LS, Devendra G, Jiyarom B, Subia N, Tallquist MD, Nerurkar VR, Chang SP, Chow DC, Shikuma CM, Park J. Phenotypic alteration of low-density granulocytes in people with pulmonary post-acute sequalae of SARS-CoV-2 infection. Front Immunol. 2022; 13:1076724. PMID: 36591237.
      Citations:    Fields:    Translation:HumansCells
    3. Dean LS, Chow DC, Ndhlovu LC, Boisvert WA, Chang SP, Shikuma CM, Park J. Characterization of Circulating Fibrocytes in People Living with HIV on Stable Antiretroviral Therapy. Immunohorizons. 2022 11 01; 6(11):760-767. PMID: 36445359.
      Citations: 1     Fields:    Translation:Humans
    4. McMillan JKP, O'Donnell P, Chang SP. Pattern recognition receptor ligand-induced differentiation of human transitional B cells. PLoS One. 2022; 17(8):e0273810. PMID: 36040923.
      Citations:    Fields:    Translation:HumansCells
    5. German GJ, Frenette C, Caissy JA, Grant J, Lefebvre MA, Mertz D, Lutes S, McGeer A, Roberts J, Afra K, Valiquette L, ?mond Y, Carrier M, Lauzon-Laurin A, Nguyen TT, Al-Bachari H, Kosar J, Peermohamed S, Science M, Landry D, MacLaggan T, Daley P, McDonald G, Ang A, Chang S, Lin YC, Tong B, Malfair S, Leung V, Katz K, Pauwels I, Goossens H, Versporten A, Conly J, Thirion DJG. The 2018 Global Point Prevalence Survey of antimicrobial consumption and resistance in 47 Canadian hospitals: a cross-sectional survey. CMAJ Open. 2021 Oct-Dec; 9(4):E1242-E1251. PMID: 34933882.
      Citations: 3     Fields:    Translation:Humans
    6. Yanagihara R, Berry MJ, Carson MJ, Chang SP, Corliss H, Cox MB, Haddad G, Hohmann C, Kelley ST, Lee ESY, Link BG, Noel RJ, Pickrel J, Porter JT, Quirk GJ, Samuel T, Stiles JK, Sy AU, Taira DA, Trepka MJ, Villalta F, Wiese TE. Building a Diverse Workforce and Thinkforce to Reduce Health Disparities. Int J Environ Res Public Health. 2021 02 07; 18(4). PMID: 33562262.
      Citations: 6     Fields:    Translation:Humans
    7. Frenette C, Sperlea D, German GJ, Afra K, Boswell J, Chang S, Goossens H, Grant J, Lefebvre MA, McGeer A, Mertz D, Science M, Versporten A, Thirion DJG. The 2017 global point prevalence survey of antimicrobial consumption and resistance in Canadian hospitals. Antimicrob Resist Infect Control. 2020 07 11; 9(1):104. PMID: 32653046.
      Citations: 12     Fields:    Translation:Humans
    8. Ching L, Chang SP, Nerurkar VR. COVID-19 Special Column: Principles Behind the Technology for Detecting SARS-CoV-2, the Cause of COVID-19. Hawaii J Health Soc Welf. 2020 05 01; 79(5):136-142. PMID: 32432217.
      Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
    9. Ofili EO, Tchounwou PB, Fernandez-Repollet E, Yanagihara R, Akintobi TH, Lee JE, Malouhi M, Garner ST, Hayes TT, Baker AR, Dent AL, Abdelrahim M, Rollins L, Chang SP, Sy A, Hernandez BY, Bullard PL, Noel RJ, Shiramizu B, Hedges JR, Berry MJ, Bond VC, Lima MF, Mokuau N, Kirken RA, Cruz-Correa M, Sarpong DF, Vadgama J, Yates C, Kahn SA, Soliman KF, Perry G, Pezzano M, Luciano CA, Barnett ME, Oyekan A, Kumar D, Norris KC. The Research Centers in Minority Institutions (RCMI) Translational Research Network: Building and Sustaining Capacity for Multi-Site Basic Biomedical, Clinical and Behavioral Research. Ethn Dis. 2019; 29(Suppl 1):135-144. PMID: 30906162.
      Citations: 18     Fields:    Translation:Humans
    10. Schirmer L, M?bius W, Zhao C, Cruz-Herranz A, Ben Haim L, Cordano C, Shiow LR, Kelley KW, Sadowski B, Timmons G, Pr?bstel AK, Wright JN, Sin JH, Devereux M, Morrison DE, Chang SM, Sabeur K, Green AJ, Nave KA, Franklin RJ, Rowitch DH. Oligodendrocyte-encoded Kir4.1 function is required for axonal integrity. Elife. 2018 09 11; 7. PMID: 30204081.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    11. Chang SP, Chun M, Guerrero A, Harris C, Kaholokula JK, Mau ML, Nakamura K, Thompson K, Zalud I. Medical School Hotline: School of Medicine Departments - Year in Review 2017, Part 2. Hawaii J Med Public Health. 2018 02; 77(2):35-37. PMID: 29435389.
      Citations:    Fields:    Translation:Humans
    12. Chang S, Linderholm A, Harper R. DUOX-Mediated Signaling Is Not Required for LPS-Induced Neutrophilic Response in the Airways. PLoS One. 2015; 10(7):e0131810. PMID: 26148206.
      Citations: 5     Fields:    Translation:AnimalsCells
    13. Sana TR, Gordon DB, Fischer SM, Tichy SE, Kitagawa N, Lai C, Gosnell WL, Chang SP. Global mass spectrometry based metabolomics profiling of erythrocytes infected with Plasmodium falciparum. PLoS One. 2013; 8(4):e60840. PMID: 23593322.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    14. Lau OS, Ng DW, Chan WW, Chang SP, Sun SS. Production of the 42-kDa fragment of Plasmodium falciparum merozoite surface protein 1, a leading malaria vaccine antigen, in Arabidopsis thaliana seeds. Plant Biotechnol J. 2010 Dec; 8(9):994-1004. PMID: 20444208.
      Citations: 7     Fields:    Translation:Animals
    15. Chang SP, Kayatani AK, Terrientes ZI, Herrera S, Leke RG, Taylor DW. Shift in epitope dominance of IgM and IgG responses to Plasmodium falciparum MSP1 block 4. Malar J. 2010 Jan 13; 9:14. PMID: 20070906.
      Citations: 1     Fields:    Translation:HumansAnimals
    16. Reed ZH, Kieny MP, Engers H, Friede M, Chang S, Longacre S, Malhotra P, Pan W, Long C. Comparison of immunogenicity of five MSP1-based malaria vaccine candidate antigens in rabbits. Vaccine. 2009 Mar 04; 27(10):1651-60. PMID: 19038302.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    17. Hawker NP, Pennypacker SD, Chang SM, Bikle DD. Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3. J Invest Dermatol. 2007 Apr; 127(4):874-80. PMID: 17082781.
      Citations: 28     Fields:    Translation:HumansCells
    18. Terrientes ZI, Vergara J, Kramer K, Herrera S, Chang SP. Restricted genetic diversity of Plasmodium falciparum major merozoite surface protein 1 in isolates from Colombia. Am J Trop Med Hyg. 2005 Nov; 73(5 Suppl):55-61. PMID: 16291768.
      Citations: 5     Fields:    Translation:HumansAnimals
    19. Schmuth M, Haqq CM, Cairns WJ, Holder JC, Dorsam S, Chang S, Lau P, Fowler AJ, Chuang G, Moser AH, Brown BE, Mao-Qiang M, Uchida Y, Schoonjans K, Auwerx J, Chambon P, Willson TM, Elias PM, Feingold KR. Peroxisome proliferator-activated receptor (PPAR)-beta/delta stimulates differentiation and lipid accumulation in keratinocytes. J Invest Dermatol. 2004 Apr; 122(4):971-83. PMID: 15102088.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    20. Xie Z, Komuves L, Yu QC, Elalieh H, Ng DC, Leary C, Chang S, Crumrine D, Yoshizawa T, Kato S, Bikle DD. Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth. J Invest Dermatol. 2002 Jan; 118(1):11-6. PMID: 11851870.
      Citations: 72     Fields:    Translation:AnimalsCells
    21. Locher CP, Tam LQ, Chang SP, McBride JS, Siddiqui WA. Plasmodium falciparum: gp195 tripeptide repeat-specific monoclonal antibody inhibits parasite growth in vitro. Exp Parasitol. 1996 Oct; 84(1):74-83. PMID: 8888734.
      Citations: 13     Fields:    Translation:AnimalsCells
    22. Hui GS, Hashimoto AC, Nikaido CM, Choi J, Chang SP. Induction of antibodies to the Plasmodium falciparum merozoite surface protein-1 (MSP1) by cross-priming with heterologous MSP1s. J Immunol. 1994 Aug 01; 153(3):1195-201. PMID: 8027549.
      Citations: 4     Fields:    Translation:AnimalsCells
    23. Chang SP, Nikaido CM, Hashimoto AC, Hashiro CQ, Yokota BT, Hui GS. Regulation of antibody specificity to Plasmodium falciparum merozoite surface protein-1 by adjuvant and MHC haplotype. J Immunol. 1994 Apr 01; 152(7):3483-90. PMID: 8144929.
      Citations: 6     Fields:    Translation:Animals
    24. Chang SP. Expression systems that best mimic native structure: which ones to try first and why. Am J Trop Med Hyg. 1994; 50(4 Suppl):11-9. PMID: 7513505.
      Citations: 1     Fields:    Translation:HumansAnimals
    25. Hui GS, Hashiro C, Nikaido C, Case SE, Hashimoto A, Gibson H, Barr PJ, Chang SP. Immunological cross-reactivity of the C-terminal 42-kilodalton fragment of Plasmodium falciparum merozoite surface protein 1 expressed in baculovirus. Infect Immun. 1993 Aug; 61(8):3403-11. PMID: 7687586.
      Citations: 9     Fields:    Translation:AnimalsCells
    26. Hui GS, Chang SP. Plasmodium falciparum: induction of biologically active antibodies to gp195 is dependent on the choice of adjuvants. Exp Parasitol. 1992 Aug; 75(1):155-7. PMID: 1639161.
      Citations: 6     Fields:    Translation:Animals
    27. Chang SP, Gibson HL, Lee-Ng CT, Barr PJ, Hui GS. A carboxyl-terminal fragment of Plasmodium falciparum gp195 expressed by a recombinant baculovirus induces antibodies that completely inhibit parasite growth. J Immunol. 1992 Jul 15; 149(2):548-55. PMID: 1624802.
      Citations: 54     Fields:    Translation:AnimalsCellsPHPublic Health
    28. Hui GS, Hashimoto A, Chang SP. Roles of conserved and allelic regions of the major merozoite surface protein (gp195) in immunity against Plasmodium falciparum. Infect Immun. 1992 Apr; 60(4):1422-33. PMID: 1548068.
      Citations: 13     Fields:    Translation:AnimalsCellsPHPublic Health
    29. Hui GS, Chang SP, Gibson H, Hashimoto A, Hashiro C, Barr PJ, Kotani S. Influence of adjuvants on the antibody specificity to the Plasmodium falciparum major merozoite surface protein, gp195. J Immunol. 1991 Dec 01; 147(11):3935-41. PMID: 1940375.
      Citations: 15     Fields:    Translation:AnimalsCells
    30. Hui GS, Tam LQ, Chang SP, Case SE, Hashiro C, Siddiqui WA, Shiba T, Kusumoto S, Kotani S. Synthetic low-toxicity muramyl dipeptide and monophosphoryl lipid A replace Freund complete adjuvant in inducing growth-inhibitory antibodies to the Plasmodium falciparum major merozoite surface protein, gp195. Infect Immun. 1991 May; 59(5):1585-91. PMID: 2019429.
      Citations: 15     Fields:    Translation:AnimalsPHPublic Health
    31. Chang SP, Hui GS, Kato A, Siddiqui WA. Generalized immunological recognition of the major merozoite surface antigen (gp195) of Plasmodium falciparum. Proc Natl Acad Sci U S A. 1989 Aug; 86(16):6343-7. PMID: 2668963.
      Citations: 16     Fields:    Translation:Animals
    32. Chang SP, Kramer KJ, Yamaga KM, Kato A, Case SE, Siddiqui WA. Plasmodium falciparum: gene structure and hydropathy profile of the major merozoite surface antigen (gp195) of the Uganda-Palo Alto isolate. Exp Parasitol. 1988 Oct; 67(1):1-11. PMID: 3049134.
      Citations: 17     Fields:    Translation:AnimalsCells
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