Richard Yanagihara
Title Director, Research Coordinating Center
Faculty Rank Professor
Degree M.D., M.P.H.
Institution University of Hawaii
Department Department of Pediatrics
Clusters Infectious and Immunological Diseases
Address
John A. Burns School of Medicine
University of Hawaii at Manoa
651 Ilalo Street, BSB320L
City Honolulu
State HI
Postal Code 96813
Telephone (808) 692-1610
Fax (808) 692-1976
Email
QR Barcode

Other Positions

Title Professor
Institution John A. Burns School of Medicine
Department Tropical Medicine, Medical Microbiology and Pharmacology

Awards and Honors

1990 National Institutes of Health Outstanding Service Medal, U.S. Public Health Service
1991 National Institutes of Health Bailey K. Ashford Medal, American Society of Tropical Medicine and Hygiene
1993 National Institutes of Health Meritorious Service Medal, U.S. Public Health Service
1993 National Institute of Infectious Diseases Senior Fellow, Japan Society for the Promotion of Science
2001 Hokkaido University School of Medicine Senior Fellow, Japan Society for the Promotion of Science
2013 International Society for Hantavirology Joel M. Dalrymple Memorial Award
2013 Korea University College of Medicine Visiting Professorship
2013 Medical University of Lódz Visiting Professorship
2014 RCMI Program Directors' Association Frederick C. Greenwood Award
2014 National Institute of Infectious Diseases Senior Fellow, Japan Society for the Promotion of Science
2016 Medical University of Lódz Visiting Professorship
2017 Achievement Rewards for College Scientists Foundation Scientist of the Year

Narrative

Dr. Richard Yanagihara, formerly a tenured intramural NIH investigator, was recruited through an interagency personnel agreement in 1995 to assist in building capacity for a laboratory-based retrovirology research program in the Research Centers in Minority Institutions (RCMI) program at the University of Hawai‘i at Manoa. He has served as the RCMI Program Director from 2000-2011, and has been the principal investigator of the Pacific Center for Emerging Infectious Diseases Research since 2003, and the director of the Research Core for the RCMI Translational Research Network since 2008. As such, he has played a critical role in coordinating the development of much-needed infrastructure for bioscience research at the university and across the RCMI community. In particular, he has been deeply involved in mentoring junior faculty, as well as developing programs that provide grant support for pilot projects and bridging funds. His extensive knowledge about the biomedical research portfolio and research resources at the 18 RCMI grantee institutions, as well as his long-standing personal relationships with RCMI investigators, makes him eminently qualified to take a leadership role in the RTRN Research Coordinating Center.

Dr. Yanagihara's own research has been conducted largely in the context of exploiting naturally occurring paradigms of high-incidence ‘place diseases’ in populations isolated by virtue of genetics, culture and/or geography. Notable among these scientific explorations, chronicled in nearly 300 publications, have been the demonstration of a cohort effect in the high-incidence focus of amyotrophic lateral sclerosis and parkinsonism-dementia among Chamorros on Guam and the discovery and characterization of genetically distinct variants of human T-cell lymphotropic virus type I in remote Melanesian populations in Papua New Guinea and Solomon Islands. In addition, his decades-long research effort on the molecular phylogeny and phylogeography of rodent-borne hantaviruses has led to the realization that shrews and moles (Order Eulipotyphla) and insectivorous bats (Order Chiroptera) may have served as the original reservoirs of ancestral hantaviruses. New knowledge and insights from this research will help to rewrite textbook chapters on hantaviruses.

Publications

1. Laenen L, Vergote V, Kafetzopoulou LE, Wawina TB, Vassou D, Cook JA, Hugot JP, Deboutte W, Kang HJ, Witkowski PT, Köppen-Rung P, Krüger DH, Licková M, Stang A, Striešková L, Szemeš T, Markowski J, Hejduk J, Kafetzopoulos D, Van Ranst M, Yanagihara R, Klempa B, Maes P. A Novel Hantavirus of the European Mole, Bruges Virus, Is Involved in Frequent Nova Virus Coinfections. Genome Biol Evol. 2018 Jan 01; 10(1):45-55.
  View in: PubMed (29272370)
 
2. Dunnum JL, Yanagihara R, Johnson KM, Armien B, Batsaikhan N, Morgan L, Cook JA. Biospecimen Repositories and Integrated Databases as Critical Infrastructure for Pathogen Discovery and Pathobiology Research. PLoS Negl Trop Dis. 2017 01; 11(1):e0005133.
  View in: PubMed (28125619)
 
3. Yanagihara R, Nerurkar VR, Hui G, Jacobs GA. Medical School Hotline: Pacific Center for Emerging Infectious Diseases Research. Hawaii J Med Public Health. 2017 01; 76(1):23-26.
  View in: PubMed (28090400)
 
4. Arai S, Taniguchi S, Aoki K, Yoshikawa Y, Kyuwa S, Tanaka-Taya K, Masangkay JS, Omatsu T, Puentespina R, Watanabe S, Alviola P, Alvarez J, Eres E, Cosico E, Quibod MNRM, Morikawa S, Yanagihara R, Oishi K. Molecular phylogeny of a genetically divergent hantavirus harbored by the Geoffroy's rousette (Rousettus amplexicaudatus), a frugivorous bat species in the Philippines. Infect Genet Evol. 2016 11; 45:26-32.
  View in: PubMed (27516187)
 
5. Kang HJ, Gu SH, Cook JA, Yanagihara R. Dahonggou Creek virus, a divergent lineage of hantavirus harbored by the long-tailed mole (Scaptonyx fusicaudus). Trop Med Health. 2016; 44:16.
  View in: PubMed (27433135)
 
6. Arai S, Kang HJ, Gu SH, Ohdachi SD, Cook JA, Yashina LN, Tanaka-Taya K, Abramov SA, Morikawa S, Okabe N, Oishi K, Yanagihara R. Genetic Diversity of Artybash Virus in the Laxmann's Shrew (Sorex caecutiens). Vector Borne Zoonotic Dis. 2016 07; 16(7):468-75.
  View in: PubMed (27172519)
 
7. Gu SH, Arai S, Yu HT, Lim BK, Kang HJ, Yanagihara R. Genetic variants of Cao Bang hantavirus in the Chinese mole shrew (Anourosorex squamipes) and Taiwanese mole shrew (Anourosorex yamashinai). Infect Genet Evol. 2016 06; 40:113-118.
  View in: PubMed (26921799)
 
8. Gu SH, Kumar M, Sikorska B, Hejduk J, Markowski J, Markowski M, Liberski PP, Yanagihara R. Isolation and partial characterization of a highly divergent lineage of hantavirus from the European mole (Talpa europaea). Sci Rep. 2016 Feb 19; 6:21119.
  View in: PubMed (26892544)
 
9. Tsunoda I, Omura S, Sato F, Kusunoki S, Fujita M, Park AM, Hasanovic F, Yanagihara R, Nagata S. Neuropathogenesis of Zika Virus Infection : Potential Roles of Antibody-Mediated Pathology. Acta Med Kinki Univ. 2016; 41(2):37-52.
  View in: PubMed (28428682)
 
10. Gu SH, Kim YS, Baek LJ, Kurata T, Yanagihara R, Song JW. Lethal disease in infant and juvenile Syrian hamsters experimentally infected with Imjin virus, a newfound crocidurine shrew-borne hantavirus. Infect Genet Evol. 2015 Dec; 36:231-239.
  View in: PubMed (26371066)
 
11. Gu SH, Hejduk J, Markowski J, Markowski M, Liberski PP, Yanagihara R. Whole-Genome Sequence of a Novel Hantavirus Isolated from the European Mole (Talpa europaea). Genome Announc. 2015 May 28; 3(3).
  View in: PubMed (26021917)
 
12. Yashina LN, Abramov SA, Dupal TA, Danchinova GA, Malyshev BS, Hay J, Gu SH, Yanagihara R. Hokkaido genotype of Puumala virus in the grey red-backed vole (Myodes rufocanus) and northern red-backed vole (Myodes rutilus) in Siberia. Infect Genet Evol. 2015 Jul; 33:304-13.
  View in: PubMed (26003760)
 
13. Gu SH, Hejduk J, Markowski J, Kang HJ, Markowski M, Polatynska M, Sikorska B, Liberski PP, Yanagihara R. Co-circulation of soricid- and talpid-borne hantaviruses in Poland. Infect Genet Evol. 2014 Dec; 28:296-303.
  View in: PubMed (25445646)
 
14. Shin OS, Song GS, Kumar M, Yanagihara R, Lee HW, Song JW. Hantaviruses induce antiviral and pro-inflammatory innate immune responses in astrocytic cells and the brain. Viral Immunol. 2014 Aug; 27(6):256-66.
  View in: PubMed (24937036)
 
15. Bennett SN, Gu SH, Kang HJ, Arai S, Yanagihara R. Reconstructing the evolutionary origins and phylogeography of hantaviruses. Trends Microbiol. 2014 Aug; 22(8):473-82.
  View in: PubMed (24852723)
 
16. Gu SH, Lim BK, Kadjo B, Arai S, Kim JA, Nicolas V, Lalis A, Denys C, Cook JA, Dominguez SR, Holmes KV, Urushadze L, Sidamonidze K, Putkaradze D, Kuzmin IV, Kosoy MY, Song JW, Yanagihara R. Molecular phylogeny of hantaviruses harbored by insectivorous bats in Côte d'Ivoire and Vietnam. Viruses. 2014 Apr 29; 6(5):1897-910.
  View in: PubMed (24784569)
 
17. Kang HJ, Stanley WT, Esselstyn JA, Gu SH, Yanagihara R. Expanded host diversity and geographic distribution of hantaviruses in sub-Saharan Africa. J Virol. 2014 Jul; 88(13):7663-7.
  View in: PubMed (24741077)
 
18. Lee JG, Gu SH, Baek LJ, Shin OS, Park KS, Kim HC, Klein TA, Yanagihara R, Song JW. Muju virus, harbored by Myodes regulus in Korea, might represent a genetic variant of Puumala virus, the prototype arvicolid rodent-borne hantavirus. Viruses. 2014 Apr 14; 6(4):1701-14.
  View in: PubMed (24736214)
 
19. Lee JG, Gu SH, Baek LJ, Shin OS, Kim HC, Klein TA, Yanagihara R, Song JW. Whole-genome sequence of muju virus, an arvicolid rodent-borne hantavirus. Genome Announc. 2014 Feb 27; 2(1).
  View in: PubMed (24578272)
 
20. Kaufusi PH, Kelley JF, Yanagihara R, Nerurkar VR. Induction of endoplasmic reticulum-derived replication-competent membrane structures by West Nile virus non-structural protein 4B. PLoS One. 2014; 9(1):e84040.
  View in: PubMed (24465392)
 
21. Yanagihara R, Gu SH, Arai S, Kang HJ, Song JW. Hantaviruses: rediscovery and new beginnings. Virus Res. 2014 Jul 17; 187:6-14.
  View in: PubMed (24412714)
 
22. Hugot JP, Gu SH, Feliu C, Ventur J, Ribas A, Dormion J, Yanagihara R, Nicolas V. Genetic Diversity of Talpa Europaea and Nova Hanta Virus (NVAV) in France. Bull Acad Vet Fr. 2014; 167(3).
  View in: PubMed (25530620)
 
23. Gu SH, Dormion J, Hugot JP, Yanagihara R. High prevalence of Nova hantavirus infection in the European mole (Talpa europaea) in France. Epidemiol Infect. 2014 Jun; 142(6):1167-71.
  View in: PubMed (24044372)
 
24. Shin OS, Kumar M, Yanagihara R, Song JW. Hantaviruses induce cell type- and viral species-specific host microRNA expression signatures. Virology. 2013 Nov; 446(1-2):217-24.
  View in: PubMed (24074584)
 
25. Gu SH, Nicolas V, Lalis A, Sathirapongsasuti N, Yanagihara R. Complete genome sequence and molecular phylogeny of a newfound hantavirus harbored by the Doucet's musk shrew (Crocidura douceti) in Guinea. Infect Genet Evol. 2013 Dec; 20:118-23.
  View in: PubMed (23994121)
 
26. Noh JY, Cheong HJ, Song JY, Kim WJ, Song KJ, Klein TA, Lee SH, Yanagihara R, Song JW. Clinical and molecular epidemiological features of hemorrhagic fever with renal syndrome in Korea over a 10-year period. J Clin Virol. 2013 Sep; 58(1):11-7.
  View in: PubMed (23871164)
 
27. Arai S, Nguyen ST, Boldgiv B, Fukui D, Araki K, Dang CN, Ohdachi SD, Nguyen NX, Pham TD, Boldbaatar B, Satoh H, Yoshikawa Y, Morikawa S, Tanaka-Taya K, Yanagihara R, Oishi K. Novel bat-borne hantavirus, Vietnam. Emerg Infect Dis. 2013 Jul; 19(7):1159-61.
  View in: PubMed (23763849)
 
28. Gu SH, Markowski J, Kang HJ, Hejduk J, Sikorska B, Liberski PP, Yanagihara R. Boginia virus, a newfound hantavirus harbored by the Eurasian water shrew (Neomys fodiens) in Poland. Virol J. 2013 May 22; 10:160.
  View in: PubMed (23693084)
 
29. Shin OS, Yanagihara R, Song JW. Distinct innate immune responses in human macrophages and endothelial cells infected with shrew-borne hantaviruses. Virology. 2012 Dec 05; 434(1):43-9.
  View in: PubMed (22944108)
 
30. Sumibcay L, Kadjo B, Gu SH, Kang HJ, Lim BK, Cook JA, Song JW, Yanagihara R. Divergent lineage of a novel hantavirus in the banana pipistrelle (Neoromicia nanus) in Côte d'Ivoire. Virol J. 2012 Jan 26; 9:34.
  View in: PubMed (22281072)
 
31. Arai S, Gu SH, Baek LJ, Tabara K, Bennett SN, Oh HS, Takada N, Kang HJ, Tanaka-Taya K, Morikawa S, Okabe N, Yanagihara R, Song JW. Divergent ancestral lineages of newfound hantaviruses harbored by phylogenetically related crocidurine shrew species in Korea. Virology. 2012 Mar 15; 424(2):99-105.
  View in: PubMed (22230701)
 
32. Kang HJ, Kosoy MY, Shrestha SK, Shrestha MP, Pavlin JA, Gibbons RV, Yanagihara R. Short report: Genetic diversity of Thottapalayam virus, a Hantavirus harbored by the Asian house shrew (Suncus murinus) in Nepal. Am J Trop Med Hyg. 2011 Sep; 85(3):540-5.
  View in: PubMed (21896819)
 
33. Kang HJ, Kadjo B, Dubey S, Jacquet F, Yanagihara R. Molecular evolution of Azagny virus, a newfound hantavirus harbored by the West African pygmy shrew (Crocidura obscurior) in Côte d'Ivoire. Virol J. 2011 Jul 28; 8:373.
  View in: PubMed (21798050)
 
34. Kang HJ, Bennett SN, Hope AG, Cook JA, Yanagihara R. Shared ancestry between a newfound mole-borne hantavirus and hantaviruses harbored by cricetid rodents. J Virol. 2011 Aug; 85(15):7496-503.
  View in: PubMed (21632770)
 
35. Gu SH, Kang HJ, Baek LJ, Noh JY, Kim HC, Klein TA, Yanagihara R, Song JW. Genetic diversity of Imjin virus in the Ussuri white-toothed shrew (Crocidura lasiura) in the Republic of Korea, 2004-2010. Virol J. 2011 Feb 08; 8:56.
  View in: PubMed (21303516)
 
36. Kang HJ, Arai S, Hope AG, Cook JA, Yanagihara R. Novel hantavirus in the flat-skulled shrew (Sorex roboratus). Vector Borne Zoonotic Dis. 2010 Aug; 10(6):593-7.
  View in: PubMed (20426682)
 
37. Yashina LN, Abramov SA, Gutorov VV, Dupal TA, Krivopalov AV, Panov VV, Danchinova GA, Vinogradov VV, Luchnikova EM, Hay J, Kang HJ, Yanagihara R. Seewis virus: phylogeography of a shrew-borne hantavirus in Siberia, Russia. Vector Borne Zoonotic Dis. 2010 Aug; 10(6):585-91.
  View in: PubMed (20426688)
 
38. Rai MA, Nerurkar VR, Khoja S, Khan S, Yanagihara R, Rehman A, Kazmi SU, Ali SH. Evidence for a "Founder Effect" among HIV-infected injection drug users (IDUs) in Pakistan. BMC Infect Dis. 2010 Jan 12; 10:7.
  View in: PubMed (20064274)
 
39. Norris KC, Yanagihara R, Tchounwou PB. Research from the eleventh RCMI International Symposium on Health Disparities. Forward. Ethn Dis. 2010; 20(1 Suppl 1):S1-1-2.
  View in: PubMed (20518454)
 
40. Kang HJ, Arai S, Hope AG, Song JW, Cook JA, Yanagihara R. Genetic diversity and phylogeography of Seewis virus in the Eurasian common shrew in Finland and Hungary. Virol J. 2009 Nov 24; 6:208.
  View in: PubMed (19930716)
 
41. Kang HJ, Bennett SN, Sumibcay L, Arai S, Hope AG, Mocz G, Song JW, Cook JA, Yanagihara R. Evolutionary insights from a genetically divergent hantavirus harbored by the European common mole (Talpa europaea). PLoS One. 2009 Jul 07; 4(7):e6149.
  View in: PubMed (19582155)
 
42. Kang HJ, Bennett SN, Dizney L, Sumibcay L, Arai S, Ruedas LA, Song JW, Yanagihara R. Host switch during evolution of a genetically distinct hantavirus in the American shrew mole (Neurotrichus gibbsii). Virology. 2009 May 25; 388(1):8-14.
  View in: PubMed (19394994)
 
43. Song JW, Kang HJ, Gu SH, Moon SS, Bennett SN, Song KJ, Baek LJ, Kim HC, O'Guinn ML, Chong ST, Klein TA, Yanagihara R. Characterization of Imjin virus, a newly isolated hantavirus from the Ussuri white-toothed shrew (Crocidura lasiura). J Virol. 2009 Jun; 83(12):6184-91.
  View in: PubMed (19357167)
 
44. Yanagihara R, Chang L, Ernst T. Building infrastructure for HIV/AIDS and mental health research at institutions serving minorities. Am J Public Health. 2009 Apr; 99 Suppl 1:S82-6.
  View in: PubMed (19246667)
 
45. Garruto RM, Yanagihara R. Contributions of isolated Pacific populations to understanding neurodegenerative diseases. Folia Neuropathol. 2009; 47(2):149-70.
  View in: PubMed (19618338)
 
46. Arai S, Ohdachi SD, Asakawa M, Kang HJ, Mocz G, Arikawa J, Okabe N, Yanagihara R. Molecular phylogeny of a newfound hantavirus in the Japanese shrew mole (Urotrichus talpoides). Proc Natl Acad Sci U S A. 2008 Oct 21; 105(42):16296-301.
  View in: PubMed (18854415)
 
47. Wu C, Nerurkar VR, Yanagihara R, Lu Y. Effective modifications for improved homologous recombination and high-efficiency generation of recombinant adenovirus-based vectors. J Virol Methods. 2008 Nov; 153(2):120-8.
  View in: PubMed (18755219)
 
48. Verma S, Molina Y, Lo YY, Cropp B, Nakano C, Yanagihara R, Nerurkar VR. In vitro effects of selenium deficiency on West Nile virus replication and cytopathogenicity. Virol J. 2008 May 31; 5:66.
  View in: PubMed (18513435)
 
49. Yang Y, Wu C, Wu J, Nerurkar VR, Yanagihara R, Lu Y. Inhibition of West Nile Virus replication by retrovirus-delivered small interfering RNA in human neuroblastoma cells. J Med Virol. 2008 May; 80(5):930-6.
  View in: PubMed (18360908)
 
50. Arai S, Bennett SN, Sumibcay L, Cook JA, Song JW, Hope A, Parmenter C, Nerurkar VR, Yates TL, Yanagihara R. Phylogenetically distinct hantaviruses in the masked shrew (Sorex cinereus) and dusky shrew (Sorex monticolus) in the United States. Am J Trop Med Hyg. 2008 Feb; 78(2):348-51.
  View in: PubMed (18256444)
 
51. Song KJ, Baek LJ, Moon S, Ha SJ, Kim SH, Park KS, Klein TA, Sames W, Kim HC, Lee JS, Yanagihara R, Song JW. Muju virus, a novel hantavirus harboured by the arvicolid rodent Myodes regulus in Korea. J Gen Virol. 2007 Nov; 88(Pt 11):3121-9.
  View in: PubMed (17947538)
 
52. Song JW, Kang HJ, Song KJ, Truong TT, Bennett SN, Arai S, Truong NU, Yanagihara R. Newfound hantavirus in Chinese mole shrew, Vietnam. Emerg Infect Dis. 2007 Nov; 13(11):1784-7.
  View in: PubMed (18217572)
 
53. Song JW, Gu SH, Bennett SN, Arai S, Puorger M, Hilbe M, Yanagihara R. Seewis virus, a genetically distinct hantavirus in the Eurasian common shrew (Sorex araneus). Virol J. 2007 Oct 30; 4:114.
  View in: PubMed (17967200)
 
54. Arai S, Song JW, Sumibcay L, Bennett SN, Nerurkar VR, Parmenter C, Cook JA, Yates TL, Yanagihara R. Hantavirus in northern short-tailed shrew, United States. Emerg Infect Dis. 2007 Sep; 13(9):1420-3.
  View in: PubMed (18252128)
 
55. Song JW, Baek LJ, Schmaljohn CS, Yanagihara R. Thottapalayam virus, a prototype shrewborne hantavirus. Emerg Infect Dis. 2007 Jul; 13(7):980-5.
  View in: PubMed (18214168)
 
56. Chapagain ML, Verma S, Mercier F, Yanagihara R, Nerurkar VR. Polyomavirus JC infects human brain microvascular endothelial cells independent of serotonin receptor 2A. Virology. 2007 Jul 20; 364(1):55-63.
  View in: PubMed (17399760)
 
57. Okumura M, Yoshimatsu K, Kumperasart S, Nakamura I, Ogino M, Taruishi M, Sungdee A, Pattamadilok S, Ibrahim IN, Erlina S, Agui T, Yanagihara R, Arikawa J. Development of serological assays for Thottapalayam virus, an insectivore-borne Hantavirus. Clin Vaccine Immunol. 2007 Feb; 14(2):173-81.
  View in: PubMed (17182762)
 
58. Baek LJ, Kariwa H, Lokugamage K, Yoshimatsu K, Arikawa J, Takashima I, Kang JI, Moon SS, Chung SY, Kim EJ, Kang HJ, Song KJ, Klein TA, Yanagihara R, Song JW. Soochong virus: an antigenically and genetically distinct hantavirus isolated from Apodemus peninsulae in Korea. J Med Virol. 2006 Feb; 78(2):290-7.
  View in: PubMed (16372283)
 
59. Zeng L, Planelles V, Sui Z, Gartner S, Maggirwar SB, Dewhurst S, Ye L, Nerurkar VR, Yanagihara R, Lu Y. HIV-1-based defective lentiviral vectors efficiently transduce human monocytes-derived macrophages and suppress replication of wild-type HIV-1. J Gene Med. 2006 Jan; 8(1):18-28.
  View in: PubMed (16142830)
 
60. Verma S, Ziegler K, Ananthula P, Co JK, Frisque RJ, Yanagihara R, Nerurkar VR. JC virus induces altered patterns of cellular gene expression: interferon-inducible genes as major transcriptional targets. Virology. 2006 Feb 20; 345(2):457-67.
  View in: PubMed (16297951)
 
61. Friedlaender J, Schurr T, Gentz F, Koki G, Friedlaender F, Horvat G, Babb P, Cerchio S, Kaestle F, Schanfield M, Deka R, Yanagihara R, Merriwether DA. Expanding Southwest Pacific mitochondrial haplogroups P and Q. Mol Biol Evol. 2005 Jun; 22(6):1506-17.
  View in: PubMed (15814828)
 
62. Lorenzo E, Colon MC, Almodovar S, Maldonado IM, Gonzalez S, Costa SE, Hill MD, Mendoza R, Sepulveda G, Yanagihara R, Nerurkar V, Kumar R, Yamamura Y, Scott WA, Kumar A. Influence of CD4+ T cell counts on viral evolution in HIV-infected individuals undergoing suppressive HAART. Virology. 2004 Dec 05; 330(1):116-26.
  View in: PubMed (15527839)
 
63. Song JW, Baek LJ, Song KJ, Skrok A, Markowski J, Bratosiewicz-Wasik J, Kordek R, Liberski PP, Yanagihara R. Characterization of Tula virus from common voles (microtus arvalis) in Poland: evidence for geographic-specific phylogenetic clustering. Virus Genes. 2004 Oct; 29(2):239-47.
  View in: PubMed (15284484)
 
64. Hoffmann PR, Woodrow RJ, Calimlim PS, Sciulli R, Effler PV, Miyamoto V, Imrie A, Yanagihara R, Nerurkar VR. West Nile virus surveillance: A simple method for verifying the integrity of RNA in mosquito (Diptera: Culicidae) pools. J Med Entomol. 2004 Jul; 41(4):731-5.
  View in: PubMed (15311468)
 
65. Lu Y, Aguirre AA, Wang Y, Zeng L, Loh PC, Yanagihara R. Viral susceptibility of newly established cell lines from the Hawaiian monk seal Monachus schauinslandi. Dis Aquat Organ. 2003 Dec 29; 57(3):183-91.
  View in: PubMed (14960030)
 
66. Nerurkar PV, Pearson L, Frank JE, Yanagihara R, Nerurkar VR. Highly active antiretroviral therapy (HAART)-associated lactic acidosis: in vitro effects of combination of nucleoside analogues and protease inhibitors on mitochondrial function and lactic acid production. Cell Mol Biol (Noisy-le-grand). 2003 Dec; 49(8):1205-11.
  View in: PubMed (14983988)
 
67. Chua PK, Yanagihara R, Melish ME, Nerurkar VR. Modulation of adhesion molecules and monocyte chemoattractant protein by tumor necrosis factor-alpha and salicylic acid in primary human coronary artery endothelial cells. Cell Mol Biol (Noisy-le-grand). 2003 Nov; 49(7):1157-66.
  View in: PubMed (14682399)
 
68. Lu YA, Wang Y, Aguirre AA, Zhao ZS, Liu CY, Nerurkar VR, Yanagihara R. RT-PCR detection of the expression of the polymerase gene of a novel reptilian herpesvirus in tumor tissues of green turtles with fibropapilloma. Arch Virol. 2003 Jun; 148(6):1155-63.
  View in: PubMed (12756620)
 
69. Chua PK, Melish ME, Yu Q, Yanagihara R, Yamamoto KS, Nerurkar VR. Elevated levels of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 during the acute phase of Kawasaki disease. Clin Diagn Lab Immunol. 2003 Mar; 10(2):308-14.
  View in: PubMed (12626459)
 
70. Shiramizu B, Yu Q, Hu N, Yanagihara R, Nerurkar VR. Investigation of TT virus in the etiology of pediatric acute lymphoblastic leukemia. Pediatr Hematol Oncol. 2002 Dec; 19(8):543-51.
  View in: PubMed (12487829)
 
71. Yanagihara R, Nerurkar VR, Scheirich I, Agostini HT, Mgone CS, Cui X, Jobes DV, Cubitt CL, Ryschkewitsch CF, Hrdy DB, Friedlaender JS, Stoner GL. JC virus genotypes in the western Pacific suggest Asian mainland relationships and virus association with early population movements. Hum Biol. 2002 Jun; 74(3):473-88.
  View in: PubMed (12180767)
 
72. Song JW, Gligic A, Yanagihara R. Identification of Tula hantavirus in Pitymys subterraneus captured in the Cacak region of Serbia-Yugoslavia. Int J Infect Dis. 2002 Mar; 6(1):31-6.
  View in: PubMed (12044299)
 
73. Yu Q, Shiramizu B, Nerurkar VR, Hu N, Shikuma CM, Melish ME, Cascio K, Imrie A, Lu Y, Yanagihara R. TT virus: preferential distribution in CD19(+) peripheral blood mononuclear cells and lack of viral integration. J Med Virol. 2002 Feb; 66(2):276-84.
  View in: PubMed (11782940)
 
74. Zheng X, Johnson C, Lu Y, Yanagihara R, Hollingshead S, Crain M, Benjamin W, Waites KB. Clinical isolates of Streptococcus pneumoniae resistant to levofloxacin contain mutations in both gyrA and parC genes. Int J Antimicrob Agents. 2001 Oct; 18(4):373-8.
  View in: PubMed (11691571)
 
75. Cubitt CL, Cui X, Agostini HT, Nerurkar VR, Scheirich I, Yanagihara R, Ryschkewitsch CF, Stoner GL. Predicted amino acid sequences for 100 JCV strains. J Neurovirol. 2001 Aug; 7(4):339-44.
  View in: PubMed (11517413)
 
76. Fernandez-Cobo M, Jobes DV, Yanagihara R, Nerurkar VR, Yamamura Y, Ryschkewitsch CF, Stoner GL. Reconstructing population history using JC virus: Amerinds, Spanish, and Africans in the ancestry of modern Puerto Ricans. Hum Biol. 2001 Jun; 73(3):385-402.
  View in: PubMed (11459420)
 
77. Yu Q, Hu N, Lu Y, Nerurkar VR, Yanagihara R. Rapid acquisition of entire DNA polymerase gene of a novel herpesvirus from green turtle fibropapilloma by a genomic walking technique. J Virol Methods. 2001 Feb; 91(2):183-95.
  View in: PubMed (11164500)
 
78. Jobe DV, Friedlaender JS, Mgone CS, Agostini HT, Koki G, Yanagihara R. New JC virus (JCV) genotypes from papua new guinea and micronesia (type 8 and type 2E) and evolutionary analysis of 32 complete JCV genomes. Arch Virol. 2001; 146(11):2097-113.
  View in: PubMed (11765914)
 
79. Buczynski J, Yanagihara R, Mora C, Cartier L, Verdugo A, Araya F, Castillo L, Gibbs CJ, Gajdusek CD, Rogers-Johnson P, Liberski PP. Tropical spastic paraparesis. Folia Neuropathol. 2001; 39(4):265-9.
  View in: PubMed (11928898)
 
80. Lin CL, Kyono W, Tongson J, Chua PK, Easa D, Yanagihara R, Nerurkar VR. Fecal excretion of a novel human circovirus, TT virus, in healthy children. Clin Diagn Lab Immunol. 2000 Nov; 7(6):960-3.
  View in: PubMed (11063506)
 
81. Song JW, Baek LJ, Kim SH, Kho EY, Kim JH, Yanagihara R, Song KJ. Genetic diversity of Apodemus agrarius-borne hantaan virus in Korea. Virus Genes. 2000 Oct; 21(3):227-32.
  View in: PubMed (11129640)
 
82. Ryschkewitsch CF, Friedlaender JS, Mgone CS, Jobes DV, Agostini HT, Chima SC, Alpers MP, Koki G, Yanagihara R, Stoner GL. Human polyomavirus JC variants in Papua New Guinea and Guam reflect ancient population settlement and viral evolution. Microbes Infect. 2000 Jul; 2(9):987-96.
  View in: PubMed (10967279)
 
83. Chua PK, Nerurkar VR, Yu Q, Woodward CL, Melish ME, Yanagihara R. Lack of association between Kawasaki syndrome and infection with parvovirus B19, human herpesvirus 8, TT virus, GB virus C/hepatitis G virus or Chlamydia pneumoniae. Pediatr Infect Dis J. 2000 May; 19(5):477-9.
  View in: PubMed (10819350)
 
84. Lu Y, Aguirre AA, Work TM, Balazs GH, Nerurkar VR, Yanagihara R. Identification of a small, naked virus in tumor-like aggregates in cell lines derived from a green turtle, Chelonia mydas, with fibropapillomas. J Virol Methods. 2000 Apr; 86(1):25-33.
  View in: PubMed (10713373)
 
85. Lu Y, Yu Q, Zamzow JP, Wang Y, Losey GS, Balazs GH, Nerurkar VR, Yanagihara R. Detection of Green Turtle Herpesviral Sequence in Saddleback Wrasse Thalassoma duperrey: A Possible Mode of Transmission of Green Turtle Fibropapilloma. J Aquat Anim Health. 2000 Mar; 12(1):58-63.
  View in: PubMed (28880781)
 
86. Lu Y, Wang Y, Yu Q, Aguirre AA, Balazs GH, Nerurkar VR, Yanagihara R. Detection of herpesviral sequences in tissues of green turtles with fibropapilloma by polymerase chain reaction. Arch Virol. 2000; 145(9):1885-93.
  View in: PubMed (11043948)
 
87. Yu Q, Lu Y, Nerurkar VR, Yanagihara R. Amplification and analysis of DNA flanking known sequences of a novel herpesvirus from green turtles with fibropapilloma Brief report. Arch Virol. 2000; 145(12):2669-76.
  View in: PubMed (11205112)
 
88. Lu Y, Aguirre AA, Hamm C, Wang Y, Yu Q, Loh PC, Yanagihara R. Establishment, cryopreservation, and growth of 11 cell lines prepared from a juvenile Hawaiian monk seal, Monachus schauinslandi. Methods Cell Sci. 2000; 22(2-3):115-24.
  View in: PubMed (11264961)
 
89. Ohkura S, Yanagihara R, Yamashita M, Hayami M. Phylogenetic relatedness of HTLV type I from Bellona, a Polynesian outlier within the Solomon Islands, to HTLV type I from Japan and far Eastern Asia. AIDS Res Hum Retroviruses. 1999 Jul 20; 15(11):1041-5.
  View in: PubMed (10445816)
 
90. Lu Y, Nerurkar VR, Aguirre AA, Work TM, Balazs GH, Yanagihara R. Establishment and characterization of 13 cell lines from a green turtle (Chelonia mydas) with fibropapillomas. In Vitro Cell Dev Biol Anim. 1999 Jul-Aug; 35(7):389-93.
  View in: PubMed (10462202)
 
91. Liberski PP, Buczynski J, Yanagihara R, Mora C, Gibbs CJ, Gajdusek C, Cartier L, Verdugo A, Araya F, Castillo L. Ultrastructural pathology of a Chilean case of tropical spastic paraparesis/human T-cell lymphotropic type I-associated myelopathy (TSP/HAM). Ultrastruct Pathol. 1999 May-Jun; 23(3):157-62.
  View in: PubMed (10445282)
 
92. Kim YK, Kim SH, Choi SH, Ko YH, Kim L, Lee MS, Suh KY, Kwak DI, Song KJ, Lee YJ, Yanagihara R, Song JW. Failure to demonstrate Borna disease virus genome in peripheral blood mononuclear cells from psychiatric patients in Korea. J Neurovirol. 1999 Apr; 5(2):196-9.
  View in: PubMed (10321984)
 
93. Iwasaki T, Tamura S, Kumasaka T, Sato Y, Hasegawa H, Asanuma H, Aizawa S, Yanagihara R, Kurata T. Exacerbation of influenzavirus pneumonia by intranasal administration of surfactant in a mouse model. Arch Virol. 1999; 144(4):675-85.
  View in: PubMed (10365160)
 
94. Nerurkar VR, Woodward CL, Nguyen HT, DeWolfe Miller F, Tashima LT, Zalles-Ganley A, Chua PK, Peterson JE, Chi PK, Hoang LT, Detels R, Yanagihara R. Lack of association between acquisition of TT virus and risk behavior for HIV and HCV infection in Vietnam. Int J Infect Dis. 1999; 3(4):181-5.
  View in: PubMed (10575145)
 
95. Lu Y, Nerurkar VR, Dashwood WM, Woodward CL, Ablan S, Shikuma CM, Grandinetti A, Chang H, Nguyen HT, Wu Z, Yamamura Y, Boto WO, Merriwether A, Kurata T, Detels R, Yanagihara R. Genotype and allele frequency of a 32-base pair deletion mutation in the CCR5 gene in various ethnic groups: absence of mutation among Asians and Pacific Islanders. Int J Infect Dis. 1999; 3(4):186-91.
  View in: PubMed (10575146)
 
96. Nerurkar VR, Chua PK, Shikuma CM, Dashwood WM, Milne CI, Woodward CL, Kobayashi G, Peterson JE, Yanagihara R. Gradual loss of IgG antibodies against GB virus C/hepatitis G virus in a patient with AIDS. Hawaii Med J. 1998 Dec; 57(12):733-4.
  View in: PubMed (9893387)
 
97. Nerurkar VR, Chua PK, Hoffmann PR, Dashwood WM, Shikuma CM, Yanagihara R. High prevalence of GB virus C/hepatitis G virus infection among homosexual men infected with human immunodeficiency virus type 1: evidence for sexual transmission. J Med Virol. 1998 Oct; 56(2):123-7.
  View in: PubMed (9746067)
 
98. Sasaki N, Fukatsu R, Tsuzuki K, Hayashi Y, Yoshida T, Fujii N, Koike T, Wakayama I, Yanagihara R, Garruto R, Amano N, Makita Z. Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases. Am J Pathol. 1998 Oct; 153(4):1149-55.
  View in: PubMed (9777946)
 
99. Nerurkar VR, Wu Z, Dashwood WM, Woodward CL, Zhang M, Detels R, Yanagihara R. Complete nef gene sequence of HIV type 1 subtype B' from professional plasma donors in the People's Republic of China. AIDS Res Hum Retroviruses. 1998 Mar 20; 14(5):461-4.
  View in: PubMed (9546806)
 
100. Gonzalez S, Tirado G, Revuelta G, Yamamura Y, Lu Y, Nerurkar VR, Yanagihara R. CCR5 chemokine receptor genotype frequencies among Puerto Rican HIV-1-seropositive individuals. Bol Asoc Med P R. 1998 Jan-Mar; 90(1-3):12-5.
  View in: PubMed (9734151)
 
101. Bertrand E, Lewandowska E, Nerurkar V, Bratosiewicz J, Yanagihara R, Zaborski J, Liberski PP. Progressive multifocal leukoencephalopathy (PML) and cerebral toxoplasmosis in an adult patient, with no symptoms of underlying immunosuppressing illness. Folia Neuropathol. 1998; 36(4):229-34.
  View in: PubMed (10079606)
 
102. Agostini HT, Yanagihara R, Davis V, Ryschkewitsch CF, Stoner GL. Asian genotypes of JC virus in Native Americans and in a Pacific Island population: markers of viral evolution and human migration. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14542-6.
  View in: PubMed (9405649)
 
103. Nerurkar VR, Nguyen HT, Woodward CL, Hoffmann PR, Dashwood WM, Long HT, Morens DM, Detels R, Yanagihara R. Sequence and phylogenetic analyses of HIV-1 infection in Vietnam: subtype E in commercial sex workers (CSW) and injection drug users (IDU). Cell Mol Biol (Noisy-le-grand). 1997 Nov; 43(7):959-68.
  View in: PubMed (9449528)
 
104. Kordek R, Liberski PP, Yanagihara R, Isaacson S, Gajdusek DC. Molecular analysis of prion protein (PrP) and glial fibrillary acidic protein (GFAP) transcripts in experimental Creutzfeldt-Jakob disease in mice. Acta Neurobiol Exp (Wars). 1997; 57(2):85-90.
  View in: PubMed (9407695)
 
105. Hironishi M, Kordek R, Yanagihara R, Garruto RM. Maltol (3-hydroxy-2-methyl-4-pyrone) toxicity in neuroblastoma cell lines and primary murine fetal hippocampal neuronal cultures. Neurodegeneration. 1996 Dec; 5(4):325-9.
  View in: PubMed (9117544)
 
106. Kordek R, Nerurkar VR, Liberski PP, Isaacson S, Yanagihara R, Gajdusek DC. Heightened expression of tumor necrosis factor alpha, interleukin 1 alpha, and glial fibrillary acidic protein in experimental Creutzfeldt-Jakob disease in mice. Proc Natl Acad Sci U S A. 1996 Sep 03; 93(18):9754-8.
  View in: PubMed (8790403)
 
107. Nerurkar VR, Nguyen HT, Dashwood WM, Hoffmann PR, Yin C, Morens DM, Kaplan AH, Detels R, Yanagihara R. HIV type 1 subtype E in commercial sex workers and injection drug users in southern Vietnam. AIDS Res Hum Retroviruses. 1996 Jun 10; 12(9):841-3.
  View in: PubMed (8738437)
 
108. Liberski PP, Yanagihara R, Brown P, Kordek R, Kloszewska I, Bratosiewicz J, Gajdusek DC. Microwave treatment enhances the immunostaining of amyloid deposits in both the transmissible and non-transmissible brain amyloidoses. Neurodegeneration. 1996 Mar; 5(1):95-9.
  View in: PubMed (8731388)
 
109. Song JW, Baek LJ, Gavrilovskaya IN, Mackow ER, Hjelle B, Yanagihara R. Sequence analysis of the complete S genomic segment of a newly identified hantavirus isolated from the white-footed mouse (Peromyscus leucopus): phylogenetic relationship with other sigmodontine rodent-borne hantaviruses. Virus Genes. 1996; 12(3):249-56.
  View in: PubMed (8883362)
 
110. Song JW, Baek LJ, Nagle JW, Schlitter D, Yanagihara R. Genetic and phylogenetic analyses of hantaviral sequences amplified from archival tissues of deer mice (Peromyscus maniculatus nubiterrae) captured in the eastern United States. Arch Virol. 1996; 141(5):959-67.
  View in: PubMed (8678841)
 
111. Hjelle B, Lee SW, Song W, Torrez-Martinez N, Song JW, Yanagihara R, Gavrilovskaya I, Mackow ER. Molecular linkage of hantavirus pulmonary syndrome to the white-footed mouse, Peromyscus leucopus: genetic characterization of the M genome of New York virus. J Virol. 1995 Dec; 69(12):8137-41.
  View in: PubMed (7494337)
 
112. Biernat W, Liberski PP, Guiroy DC, Yanagihara R, Gajdusek DC. Proliferating cell nuclear antigen immunohistochemistry in astrocytes in experimental Creutzfeldt-Jakob disease and in human kuru, Creutzfeldt-Jakob disease and Gerstmann-Sträussler-Scheinker syndrome. Neurodegeneration. 1995 Jun; 4(2):195-201.
  View in: PubMed (7583684)
 
113. Nerurkar VR, Achiron A, Song KJ, Melland RR, Pinhas-Hamiel O, Melamed E, Shohat B, Yanagihara R. Human T-cell lymphotropic virus type I in Iranian-born Mashhadi Jews: genetic and phylogenetic evidence for common source of infection. J Med Virol. 1995 Apr; 45(4):361-6.
  View in: PubMed (7666039)
 
114. Liberski PP, Budka H, Yanagihara R, Gajdusek DC. Neuroaxonal dystrophy in experimental Creutzfeldt-Jakob disease: electron microscopical and immunohistochemical demonstration of neurofilament accumulations within affected neurites. J Comp Pathol. 1995 Apr; 112(3):243-55.
  View in: PubMed (7560300)
 
115. Telford SR, Song JW, Yanagihara R. More on hantavirus in New England and New York. N Engl J Med. 1995 Feb 02; 332(5):337.
  View in: PubMed (7816081)
 
116. Liberski PP, Nerurkar VR, Yanagihara R, Gajdusek DC. Tumor necrosis factor alpha (TNF-alpha) is involved in the pathogenesis of the panencephalopathic type of Creutzfeldt-Jakob disease. Mol Chem Neuropathol. 1995 Feb-Apr; 24(2-3):223-5.
  View in: PubMed (7632323)
 
117. Song KJ, Nerurkar VR, Pereira-Cortez AJ, Yamamoto M, Taguchi H, Miyoshi I, Yanagihara R. Sequence and phylogenetic analyses of human T cell lymphotropic virus type 1 from a Brazilian woman with adult T cell leukemia: comparison with virus strains from South America and the Caribbean basin. Am J Trop Med Hyg. 1995 Jan; 52(1):101-8.
  View in: PubMed (7856818)
 
118. Lazo A, Bailer RT, Blakeslee JR, Yanagihara R, Stevens VC, Kramer L, Lairmore MD. Immune recognition of genetically diverse simian T-cell lymphotropic virus type I isolates. Arch Virol. 1995; 140(2):307-23.
  View in: PubMed (7535998)
 
119. Yanagihara R, Saitou N, Nerurkar VR, Song KJ, Bastian I, Franchini G, Gajdusek DC. Molecular phylogeny and dissemination of human T-cell lymphotropic virus type I viewed within the context of primate evolution and human migration. Cell Mol Biol (Noisy-le-grand). 1995; 41 Suppl 1:S145-61.
  View in: PubMed (8574142)
 
120. Song JW, Baek LJ, Gajdusek DC, Yanagihara R, Gavrilovskaya I, Luft BJ, Mackow ER, Hjelle B. Isolation of pathogenic hantavirus from white-footed mouse (Peromyscus leucopus) Lancet. 1994 Dec 10; 344(8937):1637.
  View in: PubMed (7984010)
 
121. Nerurkar VR, Song KJ, Bastian IB, Garin B, Franchini G, Yanagihara R. Genotyping of human T cell lymphotropic virus type I using Australo-Melanesian topotype-specific oligonucleotide primer-based polymerase chain reaction: insights into viral evolution and dissemination. J Infect Dis. 1994 Dec; 170(6):1353-60.
  View in: PubMed (7995973)
 
122. Nerurkar VR, Song JW, Song KJ, Nagle JW, Hjelle B, Jenison S, Yanagihara R. Genetic evidence for a hantavirus enzootic in deer mice (Peromyscus maniculatus) captured a decade before the recognition of hantavirus pulmonary syndrome. Virology. 1994 Nov 01; 204(2):563-8.
  View in: PubMed (7941323)
 
123. Liberski PP, Rodgers-Johnson P, Yanagihara R, Lee JW, Kramer BS, Piccardo P, Mora CA, Gibbs CJ, Gajdusek DC. Ultrastructural pathology of human T-cell lymphotropic virus type I encephalomyelopathy in a white patient with adult T-cell leukemia/lymphoma. Ultrastruct Pathol. 1994 Sep-Oct; 18(5):511-8.
  View in: PubMed (7810002)
 
124. Strong MJ, Mao K, Nerurkar VR, Wakayama I, Yanagihara R, Garruto RM. Dose-dependent selective suppression of light (NFL) and medium (NFM) but not heavy (NFH) molecular weight neurofilament mRNA levels in acute aluminum neurotoxicity. Mol Cell Neurosci. 1994 Aug; 5(4):319-26.
  View in: PubMed (7804601)
 
125. Nerurkar VR, Song KJ, Melland RR, Yanagihara R. Genetic and phylogenetic analyses of human T-cell lymphotropic virus type I variants from Melanesians with and without spastic myelopathy. Mol Neurobiol. 1994 Apr-Jun; 8(2-3):155-73.
  View in: PubMed (7999313)
 
126. Song KJ, Nerurkar VR, Saitou N, Lazo A, Blakeslee JR, Miyoshi I, Yanagihara R. Genetic analysis and molecular phylogeny of simian T-cell lymphotropic virus type I: evidence for independent virus evolution in Asia and Africa. Virology. 1994 Feb 15; 199(1):56-66.
  View in: PubMed (8116255)
 
127. Figlewicz DA, Garruto RM, Krizus A, Yanagihara R, Rouleau GA. The Cu/Zn superoxide dismutase gene in ALS and parkinsonism-dementia of Guam. Neuroreport. 1994 Jan 31; 5(5):557-60.
  View in: PubMed (8025243)
 
128. Rajcáni J, Yanagihara R, Godec MS, Nagle JW, Kudelova M, Asher DM. Low-incidence latent infection with variant B or roseola type human herpesvirus 6 in leukocytes of healthy adults. Arch Virol. 1994; 134(3-4):357-68.
  View in: PubMed (8129622)
 
129. Benson J, Tschachler E, Gessain A, Yanagihara R, Gallo RC, Franchini G. Cross-neutralizing antibodies against cosmopolitan and Melanesian strains of human T cell leukemia/lymphotropic virus type I in sera from inhabitants of Africa and the Solomon Islands. AIDS Res Hum Retroviruses. 1994 Jan; 10(1):91-6.
  View in: PubMed (8179967)
 
130. Yanagihara R. Geographic-specific genotypes or topotypes of human T-cell lymphotropic virus type I as markers for early and recent migrations of human populations. Adv Virus Res. 1994; 43:147-86.
  View in: PubMed (8191953)
 
131. Liberski PP, Yanagihara R, Nerurkar V, Gajdusek DC. Further ultrastructural studies of lesions produced in the optic nerve by tumor necrosis factor alpha (TNF-alpha): a comparison with experimental Creutzfeldt-Jakob disease. Acta Neurobiol Exp (Wars). 1994; 54(3):209-18.
  View in: PubMed (7817836)
 
132. Tanaka Y, Ishii K, Sawada T, Ohtsuki Y, Hoshino H, Yanagihara R, Miyoshi I. Prophylaxis against a Melanesian variant of human T-lymphotropic virus type I (HTLV-I) in rabbits using HTLV-I immune globulin from asymptomatically infected Japanese carriers. Blood. 1993 Dec 15; 82(12):3664-7.
  View in: PubMed (8260703)
 
133. Sherman MP, Dube S, Spicer TP, Kane TD, Love JL, Saksena NK, Iannone R, Gibbs CJ, Yanagihara R, Dube DK, et al. Sequence analysis of an immunogenic and neutralizing domain of the human T-cell lymphoma/leukemia virus type I gp46 surface membrane protein among various primate T-cell lymphoma/leukemia virus isolates including those from a patient with both HTLV-I-associated myelopathy and adult T-cell leukemia. Cancer Res. 1993 Dec 15; 53(24):6067-73.
  View in: PubMed (8261424)
 
134. Nerurkar VR, Babu PG, Song KJ, Melland RR, Gnanamuthu C, Saraswathi NK, Chandy M, Godec MS, John TJ, Yanagihara R. Sequence analysis of human T cell lymphotropic virus type I strains from southern India: gene amplification and direct sequencing from whole blood blotted onto filter paper. J Gen Virol. 1993 Dec; 74 ( Pt 12):2799-805.
  View in: PubMed (8277290)
 
135. Duenas-Barajas E, Bernal JE, Vaught DR, Nerurkar VR, Sarmiento P, Yanagihara R, Gajdusek DC. Human retroviruses in Amerindians of Colombia: high prevalence of human T cell lymphotropic virus type II infection among the Tunebo Indians. Am J Trop Med Hyg. 1993 Dec; 49(6):657-63.
  View in: PubMed (8279632)
 
136. Hoshino H, Nakamura T, Tanaka Y, Miyoshi I, Yanagihara R. Functional conservation of the neutralizing domains on the external envelope glycoprotein of cosmopolitan and melanesian strains of human T cell leukemia/lymphoma virus type I. J Infect Dis. 1993 Dec; 168(6):1368-73.
  View in: PubMed (7504032)
 
137. Nerurkar VR, Song KJ, Gajdusek DC, Yanagihara R. Genetically distinct hantavirus in deer mice. Lancet. 1993 Oct 23; 342(8878):1058-9.
  View in: PubMed (8105294)
 
138. Nerurkar VR, Song KJ, Saitou N, Melland RR, Yanagihara R. Interfamilial and intrafamilial genomic diversity and molecular phylogeny of human T-cell lymphotropic virus type I from Papua New Guinea and the Solomon Islands. Virology. 1993 Oct; 196(2):506-13.
  View in: PubMed (8372432)
 
139. Taller AM, Xiao SY, Godec MS, Gligic A, Avsic-Zupanc T, Goldfarb LG, Yanagihara R, Asher DM. Belgrade virus, a cause of hemorrhagic fever with renal syndrome in the Balkans, is closely related to Dobrava virus of field mice. J Infect Dis. 1993 Sep; 168(3):750-3.
  View in: PubMed (8102632)
 
140. Babu PG, Gnanamuthu C, Saraswathi NK, Nerurkar VR, Yanagihara R, John TJ. HTLV-I-associated myelopathy in south India. AIDS Res Hum Retroviruses. 1993 Jun; 9(6):499-500.
  View in: PubMed (8347394)
 
141. Guiroy DC, Marsh RF, Yanagihara R, Gajdusek DC. Immunolocalization of scrapie amyloid in non-congophilic, non-birefringent deposits in golden Syrian hamsters with experimental transmissible mink encephalopathy. Neurosci Lett. 1993 May 28; 155(1):112-5.
  View in: PubMed (8103204)
 
142. Nerurkar VR, Wakayama I, Rowe T, Yanagihara R, Garruto RM. Preliminary observations on the in vitro toxicity of N-butylbenzenesulfonamide: a newly discovered neurotoxin. Ann N Y Acad Sci. 1993 May 28; 679:280-7.
  View in: PubMed (8512189)
 
143. Gessain A, Boeri E, Yanagihara R, Gallo RC, Franchini G. Complete nucleotide sequence of a highly divergent human T-cell leukemia (lymphotropic) virus type I (HTLV-I) variant from melanesia: genetic and phylogenetic relationship to HTLV-I strains from other geographical regions. J Virol. 1993 Feb; 67(2):1015-23.
  View in: PubMed (8419636)
 
144. Liberski PP, Yanagihara R, Wells GA, Gajdusek DC. Bovine spongiform encephalopathy in cattle mimics ultrastructurally experimental scrapie and Creutzfeldt-Jakob disease in rodents. Neuropatol Pol. 1993; 31(1-2):1-16.
  View in: PubMed (8208436)
 
145. Guiroy DC, Mellini M, Miyazaki M, Hilbich C, Safar J, Garruto RM, Yanagihara R, Beyreuther K, Gajdusek DC. Neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonism-dementia and neurologically normal Guamanians contain a 4- to 4.5-kilodalton protein which is immunoreactive to anti-amyloid beta/A4-protein antibodies. Acta Neuropathol. 1993; 86(3):265-74.
  View in: PubMed (8213085)
 
146. Guiroy DC, Williams ES, Song KJ, Yanagihara R, Gajdusek DC. Fibrils in brain of Rocky Mountain elk with chronic wasting disease contain scrapie amyloid. Acta Neuropathol. 1993; 86(1):77-80.
  View in: PubMed (8372644)
 
147. Yanagihara R. Human T-cell lymphotropic virus type I infection and disease in the Pacific basin. Hum Biol. 1992 Dec; 64(6):843-54.
  View in: PubMed (1427742)
 
148. Duenas-Barajas E, Bernal JE, Vaught DR, Briceño I, Durán C, Yanagihara R, Gajdusek DC. Coexistence of human T-lymphotropic virus types I and II among the Wayuu Indians from the Guajira Region of Colombia. AIDS Res Hum Retroviruses. 1992 Nov; 8(11):1851-5.
  View in: PubMed (1489574)
 
149. Nerurkar VA, Yanagihara R. Specificity of an oligonucleotide primer pair and of a single-base substitution in the amplification and detection of env gene sequences of HTLV-I variants from Papua New Guinea and the Solomon Islands. AIDS Res Hum Retroviruses. 1992 Jul; 8(7):1199-200.
  View in: PubMed (1520532)
 
150. Saksena NK, Sherman MP, Yanagihara R, Dube DK, Poiesz BJ. LTR sequence and phylogenetic analyses of a newly discovered variant of HTLV-I isolated from the Hagahai of Papua New Guinea. Virology. 1992 Jul; 189(1):1-9.
  View in: PubMed (1604804)
 
151. Nerurkar VR, Miller MA, Leon-Monzon ME, Ajdukiewicz AB, Jenkins CL, Sanders RC, Godec MS, Garruto RM, Yanagihara R. Failure to isolate human T cell lymphotropic virus type I and to detect variant-specific genomic sequences by polymerase chain reaction in Melanesians with indeterminate western immunoblot. J Gen Virol. 1992 Jul; 73 ( Pt 7):1805-10.
  View in: PubMed (1629703)
 
152. Liberski PP, Yanagihara R, Wells GA, Gibbs CJ, Gajdusek DC. Comparative ultrastructural neuropathology of naturally occurring bovine spongiform encephalopathy and experimentally induced scrapie and Creutzfeldt-Jakob disease. J Comp Pathol. 1992 May; 106(4):361-81.
  View in: PubMed (1644932)
 
153. Liberski PP, Yanagihara R, Wells GA, Gibbs CJ, Gajdusek DC. Ultrastructural pathology of axons and myelin in experimental scrapie in hamsters and bovine spongiform encephalopathy in cattle and a comparison with the panencephalopathic type of Creutzfeldt-Jakob disease. J Comp Pathol. 1992 May; 106(4):383-98.
  View in: PubMed (1644933)
 
154. Sherman MP, Saksena NK, Dube DK, Yanagihara R, Poiesz BJ. Evolutionary insights on the origin of human T-cell lymphoma/leukemia virus type I (HTLV-I) derived from sequence analysis of a new HTLV-I variant from Papua New Guinea. J Virol. 1992 Apr; 66(4):2556-63.
  View in: PubMed (1548780)
 
155. Lal RB, Brodine S, Kazura J, Mbidde-Katonga E, Yanagihara R, Roberts C. Sensitivity and specificity of a recombinant transmembrane glycoprotein (rgp21)-spiked western immunoblot for serological confirmation of human T-cell lymphotropic virus type I and type II infections. J Clin Microbiol. 1992 Feb; 30(2):296-9.
  View in: PubMed (1347047)
 
156. Lal RB, Rudolph DL, Nerurkar VR, Yanagihara R. Humoral responses to the immunodominant gag and env epitopes of human T-lymphotropic virus type I among Melanesians. Viral Immunol. 1992; 5(4):265-72.
  View in: PubMed (1282011)
 
157. Liberski PP, Mirecka B, Alwasiak J, Yanagihara R, Gajdusek DC. Expression of tumor necrosis factor-alpha cachectin in primary brain tumors of astrocytic lineage. Neuropatol Pol. 1992; 30(1):35-42.
  View in: PubMed (1484608)
 
158. Liberski PP, Yanagihara R, Gibbs CJ, Gajdusek DC. Neuronal autophagic vacuoles in experimental scrapie and Creutzfeldt-Jakob disease. Acta Neuropathol. 1992; 83(2):134-9.
  View in: PubMed (1557945)
 
159. Yanagihara R, Hefner C, Ajdukiewicz AB. Human T-lymphotropic virus type I infection among blood donors in the Solomon Islands. Transfusion. 1992 Jan; 32(1):89.
  View in: PubMed (1731447)
 
160. Liberski PP, Yanagihara R, Gibbs CJ, Gajdusek DC. Mechanism of the damage to myelinated axons in experimental Creutzfeldt-Jakob disease in mice: an ultrastructural study. Eur J Epidemiol. 1991 Sep; 7(5):545-50.
  View in: PubMed (1761113)
 
161. Yanagihara R, Nerukar VR, Ajdukiewicz AB. Comparison between strains of human T lymphotropic virus type I isolated from inhabitants of the Solomon Islands and Papua New Guinea. J Infect Dis. 1991 Sep; 164(3):443-9.
  View in: PubMed (1869834)
 
162. Gessian A, Yanagihara R, Franchini G, Garruto RM, Jenkins CL, Ajdukiewicz AB, Gallo RC, Gajdusek DC. Highly divergent molecular variants of human T-lymphotropic virus type I from isolated populations in Papua New Guinea and the Solomon Islands. Proc Natl Acad Sci U S A. 1991 Sep 01; 88(17):7694-8.
  View in: PubMed (1881912)
 
163. Guiroy DC, Williams ES, Yanagihara R, Gajdusek DC. Immunolocalization of scrapie amyloid (PrP27-30) in chronic wasting disease of Rocky Mountain elk and hybrids of captive mule deer and white-tailed deer. Neurosci Lett. 1991 May 27; 126(2):195-8.
  View in: PubMed (1681473)
 
164. Xiao SY, Yanagihara R, Godec MS, Eldadah ZA, Johnson BK, Gajdusek DC, Asher DM. Detection of hantavirus RNA in tissues of experimentally infected mice using reverse transcriptase-directed polymerase chain reaction. J Med Virol. 1991 Apr; 33(4):277-82.
  View in: PubMed (1713266)
 
165. Guiroy DC, Bogucki A, Papierz W, Liberski PP, Yanagihara R. Amyloid beta-protein in cerebral amyloid angiopathy, senile plaques, and preamyloidotic lesions in subcortical arteriosclerotic encephalopathy (Binswanger disease). Neurosci Lett. 1991 Mar 11; 124(1):31-4.
  View in: PubMed (1857541)
 
166. Yanagihara R, Jenkins CL, Ajdukiewicz AB, Lal RB. Serological discrimination of HTLV I and II infection in Melanesia. Lancet. 1991 Mar 09; 337(8741):617-8.
  View in: PubMed (1671971)
 
167. Yanagihara R, Ajdukiewicz AB, Nerurkar VR, Garruto RM, Gajdusek DC. Verification of HTLV-I infection in the Solomon Islands by virus isolation and gene amplification. Jpn J Cancer Res. 1991 Mar; 82(3):240-4.
  View in: PubMed (1902446)
 
168. Yanagihara R, Nerurkar VR, Garruto RM, Miller MA, Leon-Monzon ME, Jenkins CL, Sanders RC, Liberski PP, Alpers MP, Gajdusek DC. Characterization of a variant of human T-lymphotropic virus type I isolated from a healthy member of a remote, recently contacted group in Papua New Guinea. Proc Natl Acad Sci U S A. 1991 Feb 15; 88(4):1446-50.
  View in: PubMed (1996344)
 
169. Yanagihara R, Ajdukiewicz AB, Garruto RM, Sharlow ER, Wu XY, Alemaena O, Sale H, Alexander SS, Gajudusek DC. Human T-lymphotropic virus type I infection in the Solomon Islands. Am J Trop Med Hyg. 1991 Feb; 44(2):122-30.
  View in: PubMed (2012254)
 
170. Strong MJ, Garruto RM, Wolff AV, Chou SM, Fox SD, Yanagihara R. N-butyl benzenesulfonamide: a neurotoxic plasticizer inducing a spastic myelopathy in rabbits. Acta Neuropathol. 1991; 81(3):235-41.
  View in: PubMed (2058361)
 
171. Guiroy DC, Williams ES, Yanagihara R, Gajdusek DC. Topographic distribution of scrapie amyloid-immunoreactive plaques in chronic wasting disease in captive mule deer (Odocoileus hemionus hemionus). Acta Neuropathol. 1991; 81(5):475-8.
  View in: PubMed (1713390)
 
172. Liberski PP, Yanagihara R, Gibbs CJ, Gajdusek DC. Experimental Creutzfeldt-Jakob disease: light microscopic, immunohistochemical and ultrastructural studies of the Fujisaki strain of Creutzfeldt-Jakob disease virus in NIH Swiss mice. Neuropatol Pol. 1991; 29(1-2):1-17.
  View in: PubMed (1813811)
 
173. Zhao LG, Yanagihara R, Mora C, Garruto RM, Wong TW, Gajdusek DC. Prevalence of human T-cell lymphotropic virus type I infection in Singapore: a preliminary report. Asia Pac J Public Health. 1991; 5(3):236-8.
  View in: PubMed (1823807)
 
174. Guiroy DC, Yanagihara R, Gajdusek DC. Localization of amyloidogenic proteins and sulfated glycosaminoglycans in nontransmissible and transmissible cerebral amyloidoses. Acta Neuropathol. 1991; 82(2):87-92.
  View in: PubMed (1833944)
 
175. Garruto RM, Strong MJ, Yanagihara R. Experimental models of aluminum-induced motor neuron degeneration. Adv Neurol. 1991; 56:327-40.
  View in: PubMed (1853766)
 
176. Yanagihara R, Garruto RM, Miller MA, Leon-Monzon M, Liberski PP, Gajdusek DC, Jenkins CL, Sanders RC, Alpers MP. Isolation of HTLV-I from members of a remote tribe in New Guinea. N Engl J Med. 1990 Oct 04; 323(14):993-4.
  View in: PubMed (2402266)
 
177. Strong MJ, Garruto RM, Wolff AV, Yanagihara R, Chou SM, Fox SD. N-butylbenzenesulphonamide, a novel neurotoxic plasticising agent. Lancet. 1990 Sep 08; 336(8715):640.
  View in: PubMed (1975419)
 
178. Yanagihara R, Jenkins CL, Alexander SS, Mora CA, Garruto RM. Human T lymphotropic virus type I infection in Papua New Guinea: high prevalence among the Hagahai confirmed by western analysis. J Infect Dis. 1990 Sep; 162(3):649-54.
  View in: PubMed (2387991)
 
179. Goldfarb LG, Brown P, Goldgaber D, Garruto RM, Yanagihara R, Asher DM, Gajdusek DC. Identical mutation in unrelated patients with Creutzfeldt-Jakob disease. Lancet. 1990 Jul 21; 336(8708):174-5.
  View in: PubMed (1973487)
 
180. Yanagihara R. Hantavirus infection in the United States: epizootiology and epidemiology. Rev Infect Dis. 1990 May-Jun; 12(3):449-57.
  View in: PubMed (1972804)
 
181. Garruto RM, Yanagihara R, Gajdusek DC. Models of environmentally induced neurological disease: epidemiology and etiology of amyotrophic lateral sclerosis and parkinsonism-dementia in the Western Pacific. Environ Geochem Health. 1990 Mar; 12(1-2):137-51.
  View in: PubMed (24202580)
 
182. Liberski PP, Yanagihara R, Asher DM, Gibbs CJ, Gajdusek DC. Reevaluation of the ultrastructural pathology of experimental Creutzfeldt-Jakob disease. Serial studies of the Fujisaki strain of Creutzfeldt-Jakob disease virus in mice. Brain. 1990 Feb; 113 ( Pt 1):121-37.
  View in: PubMed (2405952)
 
183. Yanagihara R, Silverman DJ. Experimental infection of human vascular endothelial cells by pathogenic and nonpathogenic hantaviruses. Arch Virol. 1990; 111(3-4):281-6.
  View in: PubMed (2112908)
 
184. Liberski PP, Yanagihara R, Gibbs CJ, Gajdusek DC. Appearance of tubulovesicular structures in experimental Creutzfeldt-Jakob disease and scrapie precedes the onset of clinical disease. Acta Neuropathol. 1990; 79(4):349-54.
  View in: PubMed (2160182)
 
185. Liberski PP, Yanagihara R, Gibbs CJ, Gajdusek DC. Spread of Creutzfeldt-Jakob disease virus along visual pathways after intraocular inoculation. Arch Virol. 1990; 111(1-2):141-7.
  View in: PubMed (2183743)
 
186. Liberski PP, Asher DM, Yanagihara R, Gibbs CJ, Gajdusek DC. Serial ultrastructural studies of scrapie in hamsters. J Comp Pathol. 1989 Nov; 101(4):429-42.
  View in: PubMed (2607015)
 
187. Liberski PP, Yanagihara R, Gibbs CJ, Gajdusek DC. Scrapie as a model for neuroaxonal dystrophy: ultrastructural studies. Exp Neurol. 1989 Nov; 106(2):133-41.
  View in: PubMed (2806455)
 
188. Garruto RM, Plato CC, Yanagihara R, Fox K, Dutt J, Gajdusek DC, Tobin J. Bone mass in Guamanian patients with amyotrophic lateral sclerosis and parkinsonism-dementia. Am J Phys Anthropol. 1989 Sep; 80(1):107-13.
  View in: PubMed (2801900)
 
189. Ajdukiewicz A, Yanagihara R, Garruto RM, Gajdusek DC, Alexander SS. HTLV-1 myeloneuropathy in the Solomon Islands. N Engl J Med. 1989 Aug 31; 321(9):615-6.
  View in: PubMed (2548101)
 
190. Gligic A, Frusic M, Obradovic M, Stojanovic R, Hlaca D, Gibbs CJ, Yanagihara R, Calisher CH, Gajdusek DC. Hemorrhagic fever with renal syndrome in Yugoslavia: antigenic characterization of hantaviruses isolated from Apodemus flavicollis and Clethrionomys glareolus. Am J Trop Med Hyg. 1989 Jul; 41(1):109-15.
  View in: PubMed (2569846)
 
191. Masullo C, Pocchiari M, Mariotti P, Macchi G, Garruto RM, Gibbs CJ, Yanagihara R, Gajdusek DC. The nucleus basalis of Meynert in parkinsonism-dementia of Guam: a morphometric study. Neuropathol Appl Neurobiol. 1989 May-Jun; 15(3):193-206.
  View in: PubMed (2747841)
 
192. Wong TW, Chan YC, Joo YG, Lee HW, Lee PW, Yanagihara R. Hantavirus infections in humans and commensal rodents in Singapore. Trans R Soc Trop Med Hyg. 1989 Mar-Apr; 83(2):248-51.
  View in: PubMed (2575293)
 
193. Shankar SK, Yanagihara R, Garruto RM, Grundke-Iqbal I, Kosik KS, Gajdusek DC. Immunocytochemical characterization of neurofibrillary tangles in amyotrophic lateral sclerosis and parkinsonism-dementia of Guam. Ann Neurol. 1989 Feb; 25(2):146-51.
  View in: PubMed (2493213)
 
194. Garruto RM, Shankar SK, Yanagihara R, Salazar AM, Amyx HL, Gajdusek DC. Low-calcium, high-aluminum diet-induced motor neuron pathology in cynomolgus monkeys. Acta Neuropathol. 1989; 78(2):210-9.
  View in: PubMed (2750490)
 
195. Liberski PP, Yanagihara R, Gibbs CJ, Gajdusek DC. White matter ultrastructural pathology of experimental Creutzfeldt-Jakob disease in mice. Acta Neuropathol. 1989; 79(1):1-9.
  View in: PubMed (2686336)
 
196. Liberski PP, Yanagihara R, Gibbs CJ, Gajdusek DC. Neuroaxonal dystrophy: an ultrastructural link between subacute spongiform virus encephalopathies and Alzheimer's disease. Prog Clin Biol Res. 1989; 317:549-57.
  View in: PubMed (2690113)
 
197. Wong TW, Chan YC, Yap EH, Joo YG, Lee HW, Lee PW, Yanagihara R, Gibbs CJ, Gajdusek DC. Serological evidence of hantavirus infection in laboratory rats and personnel. Int J Epidemiol. 1988 Dec; 17(4):887-90.
  View in: PubMed (2906333)
 
198. Baek LJ, Yanagihara R, Gibbs CJ, Miyazaki M, Gajdusek DC. Leakey virus: a new hantavirus isolated from Mus musculus in the United States. J Gen Virol. 1988 Dec; 69 ( Pt 12):3129-32.
  View in: PubMed (3143810)
 
199. Garruto RM, Yanagihara R, Gajdusek DC. Cycads and amyotrophic lateral sclerosis/parkinsonism dementia. Lancet. 1988 Nov 05; 2(8619):1079.
  View in: PubMed (2903306)
 
200. Liberski PP, Yanagihara R, Gibbs CJ, Gajdusek DC. Tubulovesicular structures in experimental Creutzfeldt-Jakob disease and scrapie. Intervirology. 1988; 29(2):115-9.
  View in: PubMed (3137185)
 
201. Yanagihara R, Amyx HL, Lee PW, Asher DM, Gibbs CJ, Gajdusek DC. Experimental hantavirus infection in nonhuman primates. Arch Virol. 1988; 101(1-2):125-30.
  View in: PubMed (3137914)
 
202. Mora CA, Garruto RM, Brown P, Guiroy D, Morgan OS, Rodgers-Johnson P, Ceroni M, Yanagihara R, Goldfarb LG, Gibbs CJ, et al. Seroprevalence of antibodies to HTLV-I in patients with chronic neurological disorders other than tropical spastic paraparesis. Ann Neurol. 1988; 23 Suppl:S192-5.
  View in: PubMed (2894813)
 
203. Piccardo P, Yanagihara R, Garruto RM, Gibbs CJ, Gajdusek DC. Histochemical and X-ray microanalytical localization of aluminum in amyotrophic lateral sclerosis and parkinsonism-dementia of Guam. Acta Neuropathol. 1988; 77(1):1-4.
  View in: PubMed (2467502)
 
204. Goudsmit J, Epstein LG, Paul DA, van der Helm HJ, Dawson GJ, Asher DM, Yanagihara R, Wolff AV, Gibbs CJ, Gajdusek DC. Intra-blood-brain barrier synthesis of human immunodeficiency virus antigen and antibody in humans and chimpanzees. Proc Natl Acad Sci U S A. 1987 Jun; 84(11):3876-80.
  View in: PubMed (3473487)
 
205. Tao H, Xia SM, Chan ZY, Song G, Yanagihara R. Morphology and morphogenesis of viruses of hemorrhagic fever with renal syndrome. II. Inclusion bodies--ultrastructural markers of hantavirus-infected cells. Intervirology. 1987; 27(1):45-52.
  View in: PubMed (3610571)
 
206. Yanagihara R, Daum CA, Lee PW, Baek LJ, Amyx HL, Gajdusek DC, Gibbs CJ. Serological survey of Prospect Hill virus infection in indigenous wild rodents in the USA. Trans R Soc Trop Med Hyg. 1987; 81(1):42-5.
  View in: PubMed (2895510)
 
207. Nara PL, Robey WG, Arthur LO, Gonda MA, Asher DM, Yanagihara R, Gibbs CJ, Gajdusek DC, Fischinger PJ. Simultaneous isolation of simian foamy virus and HTLV-III/LAV from chimpanzee lymphocytes following HTLV-III or LAV inoculation. Arch Virol. 1987; 92(1-2):183-6.
  View in: PubMed (2432853)
 
208. Garruto RM, Swyt C, Yanagihara R, Fiori CE, Gajdusek DC. Intraneuronal co-localization of silicon with calcium and aluminum in amyotrophic lateral sclerosis and parkinsonism with dementia of Guam. N Engl J Med. 1986 Sep 11; 315(11):711-2.
  View in: PubMed (3748078)
 
209. Beach RL, Rao JS, Festoff BW, Reyes ET, Yanagihara R, Gajdusek DC. Collagenase activity in skin fibroblasts of patients with amyotrophic lateral sclerosis. J Neurol Sci. 1986 Jan; 72(1):49-60.
  View in: PubMed (3005515)
 
210. Rodgers-Johnson P, Garruto RM, Yanagihara R, Chen KM, Gajdusek DC, Gibbs CJ. Amyotrophic lateral sclerosis and parkinsonism-dementia on Guam: a 30-year evaluation of clinical and neuropathologic trends. Neurology. 1986 Jan; 36(1):7-13.
  View in: PubMed (3941784)
 
211. Lee PW, Yanagihara R, Gibbs CJ, Gajdusek DC. Pathogenesis of experimental Hantaan virus infection in laboratory rats. Arch Virol. 1986; 88(1-2):57-66.
  View in: PubMed (2869749)
 
212. Garruto RM, Swyt C, Fiori CE, Yanagihara R, Gajdusek DC. Intraneuronal deposition of calcium and aluminium in amyotropic lateral sclerosis of Guam. Lancet. 1985 Dec 14; 2(8468):1353.
  View in: PubMed (2866399)
 
213. Lee PW, Gibbs CJ, Gajdusek DC, Yanagihara R. Serotypic classification of hantaviruses by indirect immunofluorescent antibody and plaque reduction neutralization tests. J Clin Microbiol. 1985 Dec; 22(6):940-4.
  View in: PubMed (2866197)
 
214. Lee PW, Amyx HL, Yanagihara R, Gajdusek DC, Goldgaber D, Gibbs CJ. Partial characterization of Prospect Hill virus isolated from meadow voles in the United States. J Infect Dis. 1985 Oct; 152(4):826-9.
  View in: PubMed (3930622)
 
215. Yanagihara R, Amyx HL, Gajdusek DC. Experimental infection with Puumala virus, the etiologic agent of nephropathia epidemica, in bank voles (Clethrionomys glareolus). J Virol. 1985 Jul; 55(1):34-8.
  View in: PubMed (2861296)
 
216. Nakamura T, Yanagihara R, Gibbs CJ, Gajdusek DC. Immune spleen cell-mediated protection against fatal Hantaan virus infection in infant mice. J Infect Dis. 1985 Apr; 151(4):691-7.
  View in: PubMed (2857753)
 
217. Yanagihara R, Chin CT, Weiss MB, Gajdusek DC, Diwan AR, Poland JB, Kleeman KT, Wilfert CM, Meiklejohn G, Glezen WP. Serological evidence of Hantaan virus infection in the United States. Am J Trop Med Hyg. 1985 Mar; 34(2):396-9.
  View in: PubMed (2858988)
 
218. Yanagihara R, Goldgaber D, Gajdusek DC. Propagation of nephropathia epidemica virus in Mongolian gerbils. J Virol. 1985 Mar; 53(3):973-5.
  View in: PubMed (3882997)
 
219. Garruto RM, Yanagihara R, Gajdusek DC. Disappearance of high-incidence amyotrophic lateral sclerosis and parkinsonism-dementia on Guam. Neurology. 1985 Feb; 35(2):193-8.
  View in: PubMed (3969206)
 
220. Nakamura T, Yanagihara R, Gibbs CJ, Amyx HL, Gajdusek DC. Differential susceptibility and resistance of immunocompetent and immunodeficient mice to fatal Hantaan virus infection. Arch Virol. 1985; 86(1-2):109-20.
  View in: PubMed (2864037)
 
221. Gajdusek DC, Amyx HL, Gibbs CJ, Asher DM, Yanagihara RT, Rodgers-Johnson P, Brown PW, Sarin PS, Gallo RC, Maluish A, et al. Transmission experiments with human T-lymphotropic retroviruses and human AIDS tissue. Lancet. 1984 Jun 23; 1(8391):1415-6.
  View in: PubMed (6145867)
 
222. Yanagihara R, Gajdusek DC, Gibbs CJ, Traub R. Prospect Hill virus: serologic evidence for infection in mammologists. N Engl J Med. 1984 May 17; 310(20):1325-6.
  View in: PubMed (6425688)
 
223. Yanagihara R, Goldgaber D, Lee PW, Amyx HL, Gajdusek DC, Gibbs CJ, Svedmyr A. Propagation of nephropathia epidemica virus in cell culture. Lancet. 1984 May 05; 1(8384):1013.
  View in: PubMed (6143926)
 
224. Garruto RM, Fukatsu R, Yanagihara R, Gajdusek DC, Hook G, Fiori CE. Imaging of calcium and aluminum in neurofibrillary tangle-bearing neurons in parkinsonism-dementia of Guam. Proc Natl Acad Sci U S A. 1984 Mar; 81(6):1875-9.
  View in: PubMed (6584922)
 
225. Yanagihara R, Garruto RM, Gajdusek DC, Tomita A, Uchikawa T, Konagaya Y, Chen KM, Sobue I, Plato CC, Gibbs CJ. Calcium and vitamin D metabolism in Guamanian Chamorros with amyotrophic lateral sclerosis and parkinsonism-dementia. Ann Neurol. 1984 Jan; 15(1):42-8.
  View in: PubMed (6546847)
 
226. Yanagihara R, Svedmyr A, Amyx HL, Lee P, Goldgaber D, Gajdusek DC, Gibbs CJ, Nyström K. Isolation and propagation of nephropathia epidemica virus in bank voles. Scand J Infect Dis. 1984; 16(3):225-8.
  View in: PubMed (6208601)
 
227. Plato CC, Greulich WW, Garruto RM, Yanagihara R. Cortical bone loss and measurements of the second metacarpal bone: II. Hypodense bone in postwar Guamanian children. Am J Phys Anthropol. 1984 Jan; 63(1):57-63.
  View in: PubMed (6703034)
 
228. Doi H, Chen KM, Chase TN, Yanagihara RT, Uebayashi Y. [Effect of L-dopa on clinical duration and quality of life of patients with Parkinsonism-dementia in Guam]. Rinsho Shinkeigaku. 1983 Nov; 23(11):935-42.
  View in: PubMed (6675879)
 
229. Yanagihara RT, Garruto RM, Gajdusek DC. Epidemiological surveillance of amyotrophic lateral sclerosis and parkinsonism-dementia in the Commonwealth of the Northern Mariana Islands. Ann Neurol. 1983 Jan; 13(1):79-86.
  View in: PubMed (6830169)
 
230. Yanagihara RH, Adler WH. Direct antiproliferative effects of cyclosporin A on murine lymphoreticular tumor cells in culture. J Biol Response Mod. 1983; 2(2):121-32.
  View in: PubMed (6606022)
 
231. Lee PW, Amyx HL, Gajdusek DC, Yanagihara RT, Goldgaber D, Gibbs CJ. New hemorrhagic fever with renal syndrome-related virus in rodents in the United States. Lancet. 1982 Dec 18; 2(8312):1405.
  View in: PubMed (6129495)
 
232. Lee PW, Goldgaber D, Gibbs CJ, Gajdusek DC, Yanagihara RT, Svedmyr A, Hlaca D, Vesenjak-Hirjan J, Gligic A. Other serotypes of hemorrhagic fever with renal syndrome viruses in Europe. Lancet. 1982 Dec 18; 2(8312):1405-6.
  View in: PubMed (6129496)
 
233. Plato CC, Garruto RM, Yanagihara RT, Chen KM, Wood JL, Gajdusek DC, Norris AH. Cortical bone loss and measurements of the second metacarpal bone. I. Comparisons between adult Guamanian Chamorros and American Caucasians. Am J Phys Anthropol. 1982 Dec; 59(4):461-5.
  View in: PubMed (7165042)
 
234. Perl DP, Gajdusek DC, Garruto RM, Yanagihara RT, Gibbs CJ. Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and Parkinsonism-dementia of Guam. Science. 1982 Sep 10; 217(4564):1053-5.
  View in: PubMed (7112111)
 
235. Lauer BA, Githens JH, Hayward AR, Conrad PD, Yanagihara RT, Tubergen DG. Probable graft-vs-graft reaction in an infant after exchange transfusion and marrow transplantation. Pediatrics. 1982 Jul; 70(1):43-7.
  View in: PubMed (6806770)
 
236. Yanagihara RH, Adler WH. Cyclosporin a inhibits T cell-mediated augmentation of mouse natural killer activity. Immunopharmacology. 1982 Jun; 4(3):243-52.
  View in: PubMed (6980868)
 
237. Svedmyr A, Lee PW, Goldgaber D, Yanagihara R, Gajdusek DC, Gibbs CJ, Nyström K. Antigenic differences between European and East Asian strains of HFRS virus. Scand J Infect Dis Suppl. 1982; 36:86-7.
  View in: PubMed (6820724)
 
238. Yanagihara R. Heavy metals and essential minerals in motor neuron disease. Adv Neurol. 1982; 36:233-47.
  View in: PubMed (7180685)
 
239. Yanagihara RT, Asher DM, Gibbs CJ, Gajdusek DC. Attempts to establish cell cultures infected with the viruses of subacute spongiform encephalopathies. Proc Soc Exp Biol Med. 1980 Nov; 165(2):298-305.
  View in: PubMed (6777783)
 
240. Yanagihara R, McIntosh K. Secretory immunological response in infants and children to parainfluenza virus types 1 and 2. Infect Immun. 1980 Oct; 30(1):23-8.
  View in: PubMed (6254881)
 
241. Goudsmit J, Morrow CH, Asher DM, Yanagihara RT, Masters CL, Gibbs CJ, Gajdusek DC. Evidence for and against the transmissibility of Alzheimer disease. Neurology. 1980 Sep; 30(9):945-50.
  View in: PubMed (6775247)
 
242. Fishaut M, Murphy N, Yanagihara R, McIntosh K. Cryopreservation of virus-infected cells for use in the fluorescent antibody to membrane antigen test. J Clin Microbiol. 1980 Jun; 11(6):687-90.
  View in: PubMed (6253517)
 
243. Yanagihara R, Todd JK. Acute febrile mucocutaneous lymph node syndrome. Am J Dis Child. 1980 Jun; 134(6):603-14.
  View in: PubMed (6104439)
 
244. Kidman AD, Yanagihara R, Asato RN. Comparative studies of bacterial hydrogenase. Biochim Biophys Acta. 1969 Sep 30; 191(1):170-3.
  View in: PubMed (4898625)