William M. Southerland
Title Professor, Dept. Biochemistry & Molecular Biology
Faculty Rank Professor,
Degree Ph.D.
Institution Howard University
Department Biochemistry & Molecular Biology
Clusters Informatics
Address
520 W Street NW
.Department of Biochemistry & Molecular Biology
City Washington
State DC
Postal Code 20059
Telephone (202) 806-9711
Fax
Email
QR Barcode

Narrative

Not Available

Publications

1. Southerland WM, Swamidass SJ, Payne PRO, Wiley L, Williams-DeVane C. The diversity and disparity in biomedical informatics (DDBI) workshop. Pac Symp Biocomput. 2018; 23:614-617.
  View in: PubMed (29218919)
 
2. Mao L, Fang Y, Campbell M, Southerland WM. Population differentiation in allele frequencies of obesity-associated SNPs. BMC Genomics. 2017 Nov 10; 18(1):861.
  View in: PubMed (29126384)
 
3. Ogindo CO, Khraiwesh MH, George M, Brandy Y, Brandy N, Gugssa A, Ashraf M, Abbas M, Southerland WM, Lee CM, Bakare O, Fang Y. Novel drug design for Chagas disease via targeting Trypanosoma cruzi tubulin: Homology modeling and binding pocket prediction on Trypanosoma cruzi tubulin polymerization inhibition by naphthoquinone derivatives. Bioorg Med Chem. 2016 08 15; 24(16):3849-55.
  View in: PubMed (27345756)
 
4. Morris KF, Billiot EJ, Billiot FH, Hoffman CB, Gladis AA, Lipkowitz KB, Southerland WM, Fang Y. Molecular Dynamics Simulation and NMR Investigation of the Association of the ß-Blockers Atenolol and Propranolol with a Chiral Molecular Micelle. Chem Phys. 2015 Aug 18; 457:133-146.
  View in: PubMed (26257464)
 
5. Morris KF, Billiot EJ, Billiot FH, Gladis AA, Lipkowitz KB, Southerland WM, Fang Y. A Molecular Dynamics Simulation Study of the Association of 1,1'-Binaphthyl-2,2'-diyl hydrogenphosphate Enantiomers with a Chiral Molecular Micelle. Chem Phys. 2014 Aug 17; 439:36-43.
  View in: PubMed (25083022)
 
6. Morris KF, Billiot EJ, Billiot FH, Lipkowitz KB, Southerland WM, Fang Y. A Molecular Dynamics Simulation Study of Two Dipeptide Based Molecular Micelles: Effect of Amino Acid Order. Open J Phys Chem. 2013 Feb 01; 3(1):20-29.
  View in: PubMed (23951550)
 
7. Morris KF, Billiot EJ, Billiot FH, Lipkowitz KB, Southerland WM, Fang Y. Investigation of Chiral Molecular Micelles by NMR Spectroscopy and Molecular Dynamics Simulation. Open J Phys Chem. 2012 Nov 01; 2(4):240-251.
  View in: PubMed (23991355)
 
8. Li H, Liu C, Burge L, Southerland W. Identification of two post-translational modifications via tandem mass spectrometry. Int J Comput Biol Drug Des. 2012; 5(3-4):314-24.
  View in: PubMed (23013656)
 
9. Zhao Y, Hao Y, Ji H, Fang Y, Guo Y, Sha W, Zhou Y, Pang X, Southerland WM, Califano JA, Gu X. Combination effects of salvianolic acid B with low-dose celecoxib on inhibition of head and neck squamous cell carcinoma growth in vitro and in vivo. Cancer Prev Res (Phila). 2010 Jun; 3(6):787-96.
  View in: PubMed (20501859)
 
10. Hu JZ, Bai L, Chen DG, Xu QT, Southerland WM. Computational investigation of the anti-HIV activity of Chinese medicinal formula Three-Huang Powder. Interdiscip Sci. 2010 Jun; 2(2):151-6.
  View in: PubMed (20640783)
 
11. Chen P, Liu C, Burge L, Li J, Mohammad M, Southerland W, Gloster C, Wang B. DomSVR: domain boundary prediction with support vector regression from sequence information alone. Amino Acids. 2010 Aug; 39(3):713-26.
  View in: PubMed (20165918)
 
12. Hu Z, Chen D, Dong L, Southerland WM. Prediction of the interaction of HIV-1 integrase and its dicaffeoylquinic acid inhibitor through molecular modeling approach. Ethn Dis. 2010; 20(1 Suppl 1):S1-45-9.
  View in: PubMed (20521384)
 
13. Fang YY, Morris VR, Lingani GM, Long EC, Southerland WM. Genome-Targeted Drug Design: Understanding the Netropsin-DNA Interaction. Open Conf Proc J. 2010; 1:157-163.
  View in: PubMed (21297883)
 
14. Chen P, Liu C, Burge L, Mahmood M, Southerland W, Gloster C. Prediction of inter-residue contact clusters from hydrophobic cores. Int J Data Min Bioinform. 2010; 4(6):722-34.
  View in: PubMed (21355503)
 
15. Hu ZJ, Bai L, Tizabi Y, Southerland W. Computational modeling study of human nicotinic acetylcholine receptor for developing new drugs in the treatment of alcoholism. Interdiscip Sci. 2009 Dec; 1(4):254-62.
  View in: PubMed (20640803)
 
16. Chen P, Liu C, Burge L, Mahmood M, Southerland W, Gloster C. Protein fold classification with genetic algorithms and feature selection. J Bioinform Comput Biol. 2009 Oct; 7(5):773-88.
  View in: PubMed (19785045)
 
17. Chen P, Liu C, Burge L, Mahmood M, Southerland W, Gloster C. Prediction of inter-residue contact clusters from hydrophobic cores. Int J Data Min Bioinform. 2008 Dec 11; 2008:703-708.
  View in: PubMed (20802820)
 
18. Jackson PL, Scott KR, Southerland WM, Fang YY. Enaminones 8: CoMFA and CoMSIA studies on some anticonvulsant enaminones. Bioorg Med Chem. 2009 Jan 01; 17(1):133-40.
  View in: PubMed (19059784)
 
19. Fleming ES, Perkins J, Easa D, Conde JG, Baker RS, Southerland WM, Dottin R, Benabe JE, Ofili EO, Bond VC, McClure SA, Sayre MH, Beanan MJ, Norris KC. The role of translational research in addressing health disparities: a conceptual framework. Ethn Dis. 2008; 18(2 Suppl 2):S2-155-60.
  View in: PubMed (18646340)
 
20. Fleming ES, Perkins J, Easa D, Conde JG, Baker RS, Southerland WM, Dottin R, Benabe JE, Ofili EO, Bond VC, McClure SA, Sayre MH, Beanan MJ, Norris KC. Addressing health disparities through multi-institutional, multidisciplinary collaboratories. Ethn Dis. 2008; 18(2 Suppl 2):S2-161-7.
  View in: PubMed (18646341)
 
21. Hu Z, Southerland W. WinDock: structure-based drug discovery on Windows-based PCs. J Comput Chem. 2007 Nov 15; 28(14):2347-51.
  View in: PubMed (17476686)
 
22. Das JR, Fryar-Tita EB, Zhou Y, Green S, Southerland WM, Bowen D. Sequence-dependent administration of 5-fluorouracil maintains methotrexate antineoplastic activity in human estrogen-negative breast cancer and protects against methotrexate cytotoxicity in human bone marrow. Anticancer Res. 2007 Nov-Dec; 27(6B):3791-9.
  View in: PubMed (18225534)
 
23. Davis JH, Desoto JA, Fryar EB, Southerland WM, Bowen D. Sequential combination chemotherapy in human breast cancer: a basis for increased antineoplastic activity and bone marrow protection. Cell Mol Biol (Noisy-le-grand). 2007 May 15; 53(3):18-26.
  View in: PubMed (17531145)
 
24. Hu Z, Bowen D, Southerland WM, del Sol A, Pan Y, Nussinov R, Ma B. Ligand binding and circular permutation modify residue interaction network in DHFR. PLoS Comput Biol. 2007 Jun; 3(6):e117.
  View in: PubMed (17571919)
 
25. Fryar-Tita EB, Das JR, Davis JH, Desoto JA, Green S, Southerland WM, Bowen D. Raloxifene and selective cell cycle specific agents: a case for the inclusion of raloxifene in current breast cancer treatment therapies. Anticancer Res. 2007 May-Jun; 27(3B):1393-9.
  View in: PubMed (17595753)
 
26. Das JR, Fryar-Tita EB, Green S, Southerland WM, Bowen D. Sequence-dependent administration of raloxifene and 5-fluorouracil/pemetrexed protects against pemetrexed cytotoxicity in human bone marrow. Anticancer Res. 2007 Mar-Apr; 27(2):825-33.
  View in: PubMed (17465208)
 
27. Nekhai S, Jerebtsova M, Jackson A, Southerland W. Regulation of HIV-1 transcription by protein phosphatase 1. Curr HIV Res. 2007 Jan; 5(1):3-9.
  View in: PubMed (17266553)
 
28. Ammosova T, Berro R, Jerebtsova M, Jackson A, Charles S, Klase Z, Southerland W, Gordeuk VR, Kashanchi F, Nekhai S. Phosphorylation of HIV-1 Tat by CDK2 in HIV-1 transcription. Retrovirology. 2006 Nov 03; 3:78.
  View in: PubMed (17083724)
 
29. Das JR, Fryar EB, Green S, Southerland WM, Bowen D. The protection against trimetrexate cytotoxicity in human bone marrow by sequence-dependent administration of raloxifene, 5-fluorouracil/trimetrexate. Anticancer Res. 2006 Nov-Dec; 26(6B):4279-86.
  View in: PubMed (17201145)
 
30. Fryar EB, Das JR, Davis JH, Desoto JA, Laniyan I, Southerland WM, Bowen D. Raloxifene attenuation of 5-FU/methotrexate cytotoxicity in human breast cancer cells: the importance of sequence in combination chemotherapy. Anticancer Res. 2006 May-Jun; 26(3A):1861-7.
  View in: PubMed (16827118)
 
31. Das JR, Fryar EB, Epie NN, Southerland WM, Bowen D. Raloxifene attenuation of methotrexate cytotoxicity in human bone marrow by sequence-dependent administration of raloxifene, 5-FU/methotrexate. Anticancer Res. 2006 May-Jun; 26(3A):1877-83.
  View in: PubMed (16827120)
 
32. Yin J, Bowen D, Southerland WM. Barnase thermal titration via molecular dynamics simulations: detection of early denaturation sites. J Mol Graph Model. 2006 Jan; 24(4):233-43.
  View in: PubMed (16213760)
 
33. Ammosova T, Jerebtsova M, Beullens M, Lesage B, Jackson A, Kashanchi F, Southerland W, Gordeuk VR, Bollen M, Nekhai S. Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein. J Biol Chem. 2005 Oct 28; 280(43):36364-71.
  View in: PubMed (16131488)
 
34. DeSoto JA, Bowen D, Southerland WM, Hawkins M, Fryar EB, Davis JH. The interaction of the steroidal antagonist faslodex and methotrexate. Cell Mol Biol (Noisy-le-grand). 2003 Nov; 49(7):1067-9.
  View in: PubMed (14682388)
 
35. De Soto JA, Bowen D, Davis JH, Southerland WM, Hawkins M. Sequence- and time-dependent antagonism between raloxifene and methotrexate in human breast cancer cells. Anticancer Res. 2002 Mar-Apr; 22(2A):1007-9.
  View in: PubMed (12014617)
 
36. Bowen D, Southerland WM, Hawkins M, Johnson DH. Sequence-dependent antagonism between tamoxifen and methotrexate in human breast cancer cells. Anticancer Res. 2000 May-Jun; 20(3A):1415-7.
  View in: PubMed (10928050)
 
37. Pitts C, Bowen D, Southerland WM. Interaction energy analyses of folate analog binding to human dihydrofolate reductase: contribution of the antifolate substructural regions to complex stability. Drug Metabol Drug Interact. 2000; 16(2):99-121.
  View in: PubMed (10962643)
 
38. Bowen D, Southerland WM, Johnson DH, Hawkins M, Hughes DE. Implications for improved high-dose methotrexate therapeutic effects in cultured human breast cancer and bone marrow cells. Cancer Detect Prev. 2000; 24(5):452-8.
  View in: PubMed (11129987)
 
39. Pan R, Bowen D, Southerland WM. Molecular modelling of trimethoprim complexes of human wild-type and mutant dihydrofolate reductases: identification of two subsets of binding residues in the antifolate binding site. Biopharm Drug Dispos. 1999 Oct; 20(7):335-40.
  View in: PubMed (10760841)
 
40. Bowen D, Johnson DH, Southerland WM, Hughes DE, Hawkins M. Selectivity in human breast cancer and human bone marrow using trimetrexate in combination with 5-fluorouracil. Anticancer Res. 1999 Sep-Oct; 19(5B):3837-40.
  View in: PubMed (10628320)
 
41. Bowen D, Johnson DH, Southerland WM, Hughes DE, Hawkins M. 5-Fluorouracil simultaneously maintains methotrexate antineoplastic activity in human breast cancer and protects against methotrexate cytotoxicity in human bone marrow. Anticancer Res. 1999 Mar-Apr; 19(2A):985-8.
  View in: PubMed (10368642)
 
42. Bowen D, Southerland WM, Bowen CD, Hughes DE. Interaction of swainsonine with lymphoid and highly perfused tissues: a pharmacokinetics explanation for sustained immunomodulation. Anticancer Res. 1997 Nov-Dec; 17(6D):4345-6.
  View in: PubMed (9494531)
 
43. Southerland WM. A molecular model of the folate binding site of Pneumocystis carinii dihydrofolate reductase. J Comput Aided Mol Des. 1994 Apr; 8(2):113-22.
  View in: PubMed (8064329)
 
44. Finch L, Southerland WM. The reaction of bisulfite with liposomal membranes. Biosci Rep. 1988 Oct; 8(5):443-8.
  View in: PubMed (3233343)