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Loyda M. Meléndez
Title Dr
Faculty Rank Professor
Degree Ph.D.
Institution University of Puerto Rico
Department Microbiology and Medical Zoology
Clusters HIV/AIDS
Address
UPR-Medical Sciences Campus
School of Medicine
P.O. Box 365067
City San Juan
State PR
Postal Code 00936-5067
Telephone 787-758-2525 xt 2816
Fax
Email
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Other Positions icon

Title Director
Institution University of Puerto Rico-Medical Sciences Campus
Department HIV Neuroimmunology Laboratory
 
Title Director
Institution University of Puerto Rico-Medical Sciences Campus
Department RCMI Translational Proteomics Center

Awards and Honors icon

1979 PR Development Company -PRIDCO Award for MS degree studies
1985 NIH MARC Award for pre-doctoral studies
1996 School of Allied Health Professional Excellence Award
1999 Glaxo-Wellcome Research Award
2001 NIH Research article in the NIH news
2009 NIH ARRA Award for research
2011 International Society for Neurovirology Research Work Highlighted ISNV Newsletter
2012 Society for Neuroimmune Pharmacology Member of the local organizing committee of the 19th Society for Neuroimmune Pharmacology meeting

Narrative icon

  Dr. Loyda M. Meléndez is Professor in the Department of Microbiology, School of Medicine and directs the RCMI Clinical Proteomics Discovery Core Facility at the University of Puerto Rico Medical Sciences Campus (UPR-MSC). The Facility provides clinical and basic researchers the proteomics instrumentation and ser-vices necessary to determine biomarkers for diseases that involve health disparities. Dr. Meléndez earned her Ph.D. degree in Experimental Pathology & Immunology cum laude from Emory University School of Medicine, where she also completed post-doctoral training in Hematology and Pediatric Infectious Diseas-es in collaboration with the Centers for Disease Control. She also has a M.S. degree magna cum laude in Microbiology from University of Georgia, Athens, and a Medical Technology degree magna cum laude from University of Puerto Rico Medical Sciences Campus. She worked in the industry from 1981-82 as Quality Control Microbiologist, and thereafter joined the UPR-MSC as Professor of Microbiologist in the School of Allied Health. After three years of teaching (1982-85), she was awarded a pre-doctoral MARC faculty fel-lowship. After completion of her PhD and Post-doctoral experience, she joined the Department of Microbi-ology and Medical Zoology of the School of Medicine at the UPR-MSC. She was Director of the Biosafety Committee at this Institution for six years. She is currently Professor of Virology and Principal Investigator of and NIH funded study to understand the mechanisms of macrophage-induced HIV neuropathogenesis using proteomics approaches. Dr. Meléndez has been a mentor of more than 30 graduate and undergrad-uate students in the field of HIV, macrophages, and vertical transmission with active funding from NIH-NCRR-RCMI (Role of HIV variants in vertical transmission), MBRS (Role of the placenta in vertical transmis-sion and protein profiling of “putative” anti-retroviral factors in placental macrophages). Since 2001 she joined the Specialized Neuroscience Program in NeuroAIDS sponsored by NIH-NINDS as a PI in the project entitled: Monocyte immunity and HIV Dementia. With this interdisciplinary project, knowledge transfer of proteomic technology was achieved from her collaborator, Dr. Howard Gendelman’s Laboratory at Univer-sity of Nebraska Medical Center. The development of five publications in the field of NeuroAIDS and prote-omics was instrumental in obtaining funding for an RCMI Core in Proteomics at UPR-MSC and subsequent R01 funding from NIHMH for the study entitled Cystatins and Cathepsins in HIV Neuropathogenesis. Dr. Meléndez is a co-inventor of one patent, has written two book chapters, and is an ad hoc reviewer for NIDA, NIMH, and NIAID and the Journals of PlosONE, Leukocyte Biology, and Placenta. She has published 43 manuscripts in National and International Journals in the areas of HIV and macrophages, and NeuroAIDS.

Mentorship icon

 
Availability Date:
Friday, February 17, 2017

I have been a mentor fro graduate and undergraduate students in research for 25 years. I also mentor young faculty in research at my institution. I can advice young faculty at external institutions.

I am available to mentor as:
HIV, NeuroAIDS, proteomics, and macrophages researcher

Programs, Membership, and Biomedical Research icon

Mentoring Mentor

NIH Awarded Grants icon

  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

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1.
2018HEAD START CONNECTS: INDIVIDUALIZING AND CONNECTS FAMILIES TO FAMILY SUPPORT SERVICESHHSP233201500059I/HHSP233201500059I
2.
2018 EARLY CARE AND EDUCATION LEADERSHIP STUDY (EXCELS)HHSP233201500035I / HHSP23337038T
3.
2018WHAT WORKS CLEARINGHOUSE OF PROVEN AND PROMISING APPROACHES TO MOVE WELFARE RECIPIENTS TO WORKHHSP233201500035I_HHSP23337034T
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2018RACIAL AND ETHNIC DISPARITIES IN HUMAN SERVICES ANALYSIS EXECUTION PROJECTHHSP233201500064I_HHSP23337020T
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2018ASSESSING MODELS OF COORDINATED SERVICES FOR LOW-INCOME CHILDREN AND THEIR FAMILIESHHSP233201500035I/HHSP23337028T
6.
2018CHILD CARE INTERSTATE BACKGROUND CHECKS (CC-IBACS)HHSP233201500045I
7.
2018MOTHER AND INFANT HOME VISITING PROGRAM EVALUATION, LONG-TERM FOLLOW-UP 2 (MIHOPE-LT2)HHSP233201500059I/ HHSP23337010T
8.
2017EXPLORING THE RELATION BETWEEN POSITIVE BEHAVIOR SUPPORT AND LANGUAGE LEARNING OPPORTUNITIES IN PRESCHOOL CLASSROOMS.90YR0101-01
9.
2017ADDRESSING THE NEEDS OF INFANTS AND TODDLERS EXPOSED TO MALTREATMENT: EXAMINING THE IMPACT OF AN INTEGRATED EARLY HEAD START & CHILDREN AND YOUTH SERVICES PROGRAM90YR0102-01
10.
2017LEVERAGING HOME LANGUAGES TO PROMOTE EXECUTIVE FUNCTIONING90YR0103-01
11.
2017A STRENGTHS-BASED APPROACH TO EXAMINING SUPPORTS FOR SELF-REGULATION SKILLS OF LATINO CHILDREN RAISED IN POVERTY90YR0104-01
12.
2017OBSERVING SELF-REGULATION IN CONTEXT IN HEAD START CLASSROOMS AND DUAL LANGUAGE LEARNERS SCHOOL READINESS90YR0105-01
13.
2017IMPLEMENTATION AND ASSESSMENT OF COMPETENCIES FOR TEACHERS AND CAREGIVERS SERVING INFANTS AND TODDLERSHHSP233201500035I/HHSP23337021T
14.
2017ASSESSMENT AND MAPPING OF COMMUNITY CONNECTIONS IN HOME VISITING (AMC-HV)HHSP233201500034I/HHSP23337002T
15.
2017CHILD MALTREATMENT INCIDENCE DATA LINKAGES (CMI DATA LINKAGES)HHSP233201500035I/HHSP23337022T
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2017EVIDENCE BUILDING IN TANF: ADVANCING INNOVATIONS TO PROMOTE EMPLOYMENT AND ECONOMIC SECURITY FOR LOW-INCOME INDIVIDUALSHHSP233201500059I/HHSP23337006T
17.
2017HEAD START FAMILY AND CHILD EXPERIENCES SURVEY (FACES) 2019HHSP233201500035I/HHSP23337024T
18.
2016TWO-GENERATION APPROACHES TO IMPROVING FAMILY SELF-SUFFICIENCYHHSP233201500035I/HHSP23337003T
19.
2016BUILDING CAPACITY TO EVALUATE INTERVENTIONS FOR YOUTH/YOUNG ADULTS WITH CHILD WELFARE INVOLVEMENT AT-RISK OF HOMELESSNESS: PHASE IIHHSP233201500035I/HHSP23337013T
20.
2016PROFESSIONAL DEVELOPMENT TOOLS TO IMPROVE THE QUALITY OF INFANT AND TODDLER CAREHHSP233201500035I/HHSP23337007T
21.
2016ASSESSING THE EVIDENCE: HOME VISITING EVIDENCE OF EFFECTIVENESSGS-10F-0050L/HHSP233201500115G
22.
2016TRIBAL HOME VISITING EVALUATION INSTITUTEGS-10F-0204K/HHSP233201500114G
23.
2016FAMILY SELF-SUFFICIENCY DATA CENTER90PD0272-04
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2016EVALUATION OF GOAL-DIRECTED PSYCHOLOGICAL CAPITAL AND EMPLOYER COACHING IN HEALTH PROFESSION OPPORTUNITY DEVELOPMENT90HG1003-01
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2016CULTURE OF CONTINUOUS LEARNING PROJECT: A BREAKTHROUGH SERIES COLLABORATIVE FOR IMPROVING CHILD CARE AND HEAD START QUALITYHHSP233201500034I/HHSP23337001T
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2016DOMESTIC HUMAN TRAFFICKING AND THE CHILD WELFARE POPULATIONHHSP23320150039I/HHSP23337011T
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2016EVALUATION OF COACHING-FOCUSED INTERVENTIONS FOR HARD-TO-EMPLOY TANF CLIENTS AND OTHER LOW-INCOME POPULATIONSHHSP233201500035I/HHSP23337018T
28.
2016EVALUATION OF THE NATIONAL HUMAN TRAFFICKING HOTLINE PROGRAMHHSP233201500039I/ HHSP23337007T
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2016MULTI-SITE IMPLEMENTATION EVALUATION OF TRIBAL HOME VISITING (MUSE)HHSP233201500133I/HHSP23337004T
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2016VARIATIONS IN IMPLEMENTATION OF QUALITY INTERVENTIONS: EXAMINING THE QUALITY-CHILD OUTCOMES RELATIONSHIP IN CHILD CARE AND EARLY EDUCATION (VIQI)HHSP233201500059I/HHSP23337002T
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2016DESIGN OPTIONS FOR HOME VISITING EVALUATION (DOHVE) 2.0HHSP233201500133I/HHSP23337002T
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2016ADVANCING WELFARE AND FAMILY SELF-SUFFICIENCY RESEARCH PROJECT (FOLLOW-ON) HHSP233201500035I/HHSP23337017T
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2016HPOG UNIVERSITY PARTNERSHIPS 2.0 RESEARCH SUPPORTHHSP233201500071I/HHSP23337011T
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2015THE CHANGING LANDSCAPE OF PUBLICLY-FUNDED CENTER-BASED CHILD CARE: 1990 AND 2012.90YE0165-01
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2015SUBSIDY UTILIZATION AND IMPACT ON EARLY CARE AND EDUCATION OF LOW-INCOME CHILDREN WITH SPECIAL NEEDS90YE0166-01
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2015PROMOTING SOCIAL COMPETENCE IN ECE: PREDICTING THE DEVELOPMENT OF PROSOCIAL BEHAVIOR FROM EARLY EXPERIENCES IN CHILD CARE AND FAMILIES90YE0168-01
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2015THE IMPACT OF EARLY CARE AND EDUCATION IN CHILD NUTRITION, SEDENTARY BEHAVIOR AND OBESITY BY KINDERGARTEN90YE0170-01
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2015HOW PARENTAL PREFERENCES AND SUBSIDY RECEIPT SHAPE IMMIGRANT FAMILIES? CHILD CARE CHOICES90YE0171-01
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2015SUPPORTING LOW-INCOME FAMILIES: STATE VARIATIONS IN CHILD CARE SUBSIDIES AND TANF POLICIES AND CHILDREN'S DEVELOPMENTAL ECOLOGIES90YE0173-01
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2015MITIGATING SUSCEPTIBILITY WITH THE CHILD CARE DEVELOPMENT FUND: USING FOUR LARGE DATA SETS TO CLASSIFY RISK PROFILES AND RISK TRANSMISSION BY MODIFIABLE FACTORS90YE0175-01
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2015ARE HIGHER SUBSIDY PAYMENT RATES AND PROVIDER-FRIENDLY PAYMENT POLICIES ASSOCIATED WITH CHILD CARE QUALITY?90YE0177-01
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2015CHILD CARE FACTORS THAT INFLUENCE PARENTAL ENGAGEMENT: UNDERSTANDING LONGITUDINAL PATHWAYS TO CHILDREN?S SCHOOL READINESS90YE0178-01
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2015CONSTELLATIONS OF SUPPORT: TEACHER PROFESSIONAL DEVELOPMENT IN HEAD START AND CHILD OUTCOMES90YE0179-01
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2015SUHMRE: SAME-SEX RELATIONSHIPS: UPDATES TO HEALTHY MARRIAGE AND RELATIONSHIP EDUCATION PROGRAMMINGHHSP233201500064I/HHSP23337001T
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2014ASSESSING THE COST AND IMPLEMENTATION OF HIGH QUALITY EARLY CARE AND EDUCATION (ACIHQECE)HHSP23320095642WC-01
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2014INTERMEDIATE OUTCOMES OF CAREER PATHWAYS PROGRAMSHHSP233200956WC-01
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2014CHILD CARE AND DEVELOPMENT FUND (CCDF) POLICIES DATABASE PROJECTHHSP23320095654WC-01
48.
2014EVALUATION OF DOMESTIC HUMAN TRAFFICKING DEMONSTRATION PROJECTSHHSP23320095651WC-01
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2014HOMELESS FAMILIES RESEARCH BRIEFSHHSP23320095624WC-01
50.
2014RESPONDING TO INTIMATE VIOLENCE IN RELATIONSHIP PROGRAMS (RIVIR)HHSP23320095651WC-01
51.
2014UNDERSTANDING THE INTERSECTION BETWEEN TANF AND REFUGEE CASH ASSISTANCE SERVICESHHSP23320095624WC-01
52.
2014IMPROVING CHILDREN?S WELL-BEING: IDENTIFYING MECHANISMS AND TIMING OF FAMILY STRENGTHENING PROGRAMS FOR LOW-INCOME FAMILIES THROUGH DIFFERENTIAL EQUATION MODELING90PD0285-01
53.
2013MOTHER AND INFANT HOME VISITING PROGRAM EVALUATION (MIHOPE)HHSP23337003T-03
54.
2013STUDY OF EMPLOYMENT AND ADVANCEMENT OF RACIAL, ETHNIC AND LINGUISTIC MINORITIES90PH0021-02
55.
2013CHILD CARE AND EARLY EDUCATION POLICY AND RESEARCH ANALYSES (CCEEPRA)HHSP23320095631WC-01
56.
2013EARLY HEAD START-CHILD CARE PARTNERSHIPS STUDYHHSP23320095642WC-01
57.
2013EMPLOYMENT AND TRAINING EVIDENCE REVIEWHHSP23320095642WC-01
58.
2013MATERNAL, INFANT AND EARLY CHILDHOOD HOME VISITING EVALUATION (MIHOPE) IIHHSP23320095644WC-01
59.
2013JOB SEARCH ASSISTANCE EVALUATIONHHSP23320095624WC-01
60.
2013CHILD CARE ADMINISTRATIVE DATA ANALYSIS90YE0148-01
61.
2013HEAD START UNIVERSITY PARTNERSHIPS: DUAL GENERATION APPROACHES90YR0073-01
62.
2013HEAD START UNIVERSITY PARTNERSHIPS: DUAL GENERATION APPROACHES90YR0075-01
63.
2013HUMAN SERVICES RESEARCH PARTNERSHIPS: PUERTO RICO 90YR0072-01

Publications icon

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1. Santana-Rivera Y, Rabelo-Fernández RJ, Quiñones-Díaz BI, Grafals-Ruíz N, Santiago-Sánchez G, Lozada-Delgado EL, Echevarría-Vargas IM, Apiz J, Soto D, Rosado A, Meléndez L, Valiyeva F, Vivas-Mejía PE. Reduced expression of enolase-1 correlates with high intracellular glucose levels and increased senescence in cisplatin-resistant ovarian cancer cells. Am J Transl Res. 2020; 12(4):1275-1292.
2. López OV, Gorantla S, Segarra AC, Andino Norat MC, Álvarez M, Skolasky RL, Meléndez LM. Sigma-1 Receptor Antagonist (BD1047) Decreases Cathepsin B Secretion in HIV-Infected Macrophages Exposed to Cocaine. J Neuroimmune Pharmacol. 2019 06; 14(2):226-240.
3. Rosario-Rodríguez LJ, Colón K, Borges-Vélez G, Negrón K, Meléndez LM. Dimethyl Fumarate Prevents HIV-Induced Lysosomal Dysfunction and Cathepsin B Release from Macrophages. J Neuroimmune Pharmacol. 2018 09; 13(3):345-354.
4. Cantres-Rosario YM, Acevedo-Mariani FM, Pérez-Laspiur J, Haskins WE, Plaud M, Cantres-Rosario YM, Skolasky R, Méndez-Bermúdez I, Wojna V, Meléndez LM. Microwave & magnetic proteomics of macrophages from patients with HIV-associated cognitive impairment. PLoS One. 2017; 12(7):e0181779.
5. Martínez-Rivera FJ, Pérez-Laspiur J, Santiago-Gascot ME, Alemán-Reyes AG, García-Santiago E, Rodríguez-Pérez Y, Calo-Guadalupe C, Otero-Pagán I, Ayala-Pagán RN, Martínez M, Cantres-Rosario YM, Meléndez LM, Barreto-Estrada JL. Differential protein expression profile in the hypothalamic GT1-7 cell line after exposure to anabolic androgenic steroids. PLoS One. 2017; 12(7):e0180409.
6. Rivera LE, Kraiselburd E, Meléndez LM. Cystatin B and HIV regulate the STAT-1 signaling circuit in HIV-infected and INF-ß-treated human macrophages. J Neurovirol. 2016 10; 22(5):666-673.
7. Delgado-Vélez M, Báez-Pagán CA, Gerena Y, Quesada O, Santiago-Pérez LI, Capó-Vélez CM, Wojna V, Meléndez L, León-Rivera R, Silva W, Lasalde-Dominicci JA. The a7-nicotinic receptor is upregulated in immune cells from HIV-seropositive women: consequences to the cholinergic anti-inflammatory response. Clin Transl Immunology. 2015 Dec; 4(12):e53.
8. Zenón F, Jorge I, Cruz A, Suárez E, Segarra AC, Vázquez J, Meléndez LM, Serrano H. 18O proteomics reveal increased human apolipoprotein CIII in Hispanic HIV-1+ women with HAART that use cocaine. Proteomics Clin Appl. 2016 Feb; 10(2):144-55.
9. Cantres-Rosario YM, Hernandez N, Negron K, Perez-Laspiur J, Leszyk J, Shaffer SA, Meléndez LM. Interacting partners of macrophage-secreted cathepsin B contribute to HIV-induced neuronal apoptosis. AIDS. 2015 Oct 23; 29(16):2081-92.
10. Colón K, Vázquez-Santiago F, Rivera-Amill V, Delgado G, Massey SE, Wojna V, Noel RJ, Meléndez LM. HIV gp120 sequence variability associated with HAND in Hispanic Women. J Virol Antivir Res. 2015; 4(3).
11. Vázquez-Santiago F, García Y, Rivera-Román I, Noel RJ, Wojna V, Meléndez LM, Rivera-Amill V. Longitudinal Analysis of Cerebrospinal Fluid and Plasma HIV-1 Envelope Sequences Isolated From a Single Donor with HIV Asymptomatic Neurocognitive Impairment. J Virol Antivir Res. 2015; 4(1).
12. Zenón F, Segarra AC, Gonzalez M, Meléndez LM. Cocaine potentiates cathepsin B secretion and neuronal apoptosis from HIV-infected macrophages. J Neuroimmune Pharmacol. 2014 Dec; 9(5):703-15.
13. Agsalda-Garcia M, Shiramizu B, Melendez L, Plaud M, Liang CY, Wojna V. Different levels of HIV DNA copy numbers in cerebrospinal fluid cellular subsets. J Health Care Poor Underserved. 2013 Nov; 24(4 Suppl):8-16.
14. Cantres-Rosario Y, Plaud-Valentín M, Gerena Y, Skolasky RL, Wojna V, Meléndez LM. Cathepsin B and cystatin B in HIV-seropositive women are associated with infection and HIV-1-associated neurocognitive disorders. AIDS. 2013 Jan 28; 27(3):347-56.
15. Rodriguez-Franco EJ, Cantres-Rosario YM, Plaud-Valentin M, Romeu R, Rodríguez Y, Skolasky R, Meléndez V, Cadilla CL, Melendez LM. Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis. PLoS One. 2012; 7(5):e36571.
16. Rivera-Rivera L, Perez-Laspiur J, Colón K, Meléndez LM. Inhibition of interferon response by cystatin B: implication in HIV replication of macrophage reservoirs. J Neurovirol. 2012 Feb; 18(1):20-9.
17. Meléndez LM, Colon K, Rivera L, Rodriguez-Franco E, Toro-Nieves D. Proteomic analysis of HIV-infected macrophages. J Neuroimmune Pharmacol. 2011 Mar; 6(1):89-106.
18. Kraft-Terry S, Gerena Y, Wojna V, Plaud-Valentin M, Rodriguez Y, Ciborowski P, Mayo R, Skolasky R, Gendelman HE, Meléndez LM. Proteomic analyses of monocytes obtained from Hispanic women with HIV-associated dementia show depressed antioxidants. Proteomics Clin Appl. 2010 Sep; 4(8-9):706-14.
19. García-Crespo K, Cadilla C, Skolasky R, Meléndez LM. Restricted HIV-1 replication in placental macrophages is caused by inefficient viral transcription. J Leukoc Biol. 2010 Apr; 87(4):633-6.
20. Luciano-Montalvo C, Meléndez LM. Cystatin B associates with signal transducer and activator of transcription 1 in monocyte-derived and placental macrophages. Placenta. 2009 May; 30(5):464-7.
21. Toro-Nieves DM, Rodriguez Y, Plaud M, Ciborowski P, Duan F, Pérez Laspiur J, Wojna V, Meléndez LM. Proteomic analyses of monocyte-derived macrophages infected with human immunodeficiency virus type 1 primary isolates from Hispanic women with and without cognitive impairment. J Neurovirol. 2009 Jan; 15(1):36-50.
22. Velázquez I, Plaud M, Wojna V, Skolasky R, Laspiur JP, Meléndez LM. Antioxidant enzyme dysfunction in monocytes and CSF of Hispanic women with HIV-associated cognitive impairment. J Neuroimmunol. 2009 Jan 03; 206(1-2):106-11.
23. García K, García V, Pérez Laspiur J, Duan F, Meléndez LM. Characterization of the placental macrophage secretome: implications for antiviral activity. Placenta. 2009 Feb; 30(2):149-55.
24. Luciano-Montalvo C, Ciborowski P, Duan F, Gendelman HE, Meléndez LM. Proteomic analyses associate cystatin B with restricted HIV-1 replication in placental macrophages. Placenta. 2008 Dec; 29(12):1016-23.
25. Wojna V, Robles L, Skolasky RL, Mayo R, Selnes O, de la Torre T, Maldonado E, Nath A, Meléndez LM, Lasalde-Dominicci J. Associations of cigarette smoking with viral immune and cognitive function in human immunodeficiency virus-seropositive women. J Neurovirol. 2007 Dec; 13(6):561-8.
26. Laspiur JP, Anderson ER, Ciborowski P, Wojna V, Rozek W, Duan F, Mayo R, Rodríguez E, Plaud-Valentín M, Rodríguez-Orengo J, Gendelman HE, Meléndez LM. CSF proteomic fingerprints for HIV-associated cognitive impairment. J Neuroimmunol. 2007 Dec; 192(1-2):157-70.
27. Rozek W, Ricardo-Dukelow M, Holloway S, Gendelman HE, Wojna V, Melendez LM, Ciborowski P. Cerebrospinal fluid proteomic profiling of HIV-1-infected patients with cognitive impairment. J Proteome Res. 2007 Nov; 6(11):4189-99.
28. Nieves DM, Plaud M, Wojna V, Skolasky R, Meléndez LM. Characterization of peripheral blood human immunodeficiency virus isolates from Hispanic women with cognitive impairment. J Neurovirol. 2007 Aug; 13(4):315-27.
29. Wojna V, Skolasky RL, Hechavarría R, Mayo R, Selnes O, McArthur JC, Meléndez LM, Maldonado E, Zorrilla CD, García H, Kraiselburd E, Nath A. Prevalence of human immunodeficiency virus-associated cognitive impairment in a group of Hispanic women at risk for neurological impairment. J Neurovirol. 2006 Oct; 12(5):356-64.
30. Wojna V, Carlson KA, Luo X, Mayo R, Meléndez LM, Kraiselburd E, Gendelman HE. Proteomic fingerprinting of human immunodeficiency virus type 1-associated dementia from patient monocyte-derived macrophages: A case study. J Neurovirol. 2004; 10 Suppl 1:74-81.
31. Luo X, Carlson KA, Wojna V, Mayo R, Biskup TM, Stoner J, Anderson J, Gendelman HE, Meléndez LM. Macrophage proteomic fingerprinting predicts HIV-1-associated cognitive impairment. Neurology. 2003 Jun 24; 60(12):1931-7.

Original Articles icon

 

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1. Rivera LE, Kraiselburd E, Meléndez LM. J Neurovirol. Cystatin B and HIV regulate the STAT-1 signaling circuit in HIV-infected and INF-β-treated human macrophages. 2016; 22(5):666-673.
2. Delgado-Vélez M, Báez-Pagán CA, Gerena Y, Quesada O, Santiago-Pérez LI, Capó-Vélez CM, Wojna V, Meléndez L, León-Rivera R, Silva W, Lasalde-Dominicci JA. Clin Transl Immunology. The α7-nicotinic receptor is upregulated in immune cells from HIV-seropositive women: consequences to the cholinergic anti-inflammatory response. 2015; 4(12):e53.
3. Zenón F, Jorge I, Cruz A, Suárez E, Segarra AC, Vázquez J, Meléndez LM, Serrano H. . Proteomics Clin Appl. 18O proteomics reveal increased human apolipoprotein CIII in Hispanic HIV-1+ women with HAART that use cocaine. 2015; 10(2):144-55.
4. Colon K, Perez-Laspiur J, Quiles R, Rodriguez Y, Wojna V, Shaffer SA, Leszyk J, Skolasky RL Jr, Melendez LM. . Proteomics Clin Appl. Macrophage secretome from women with HIV-associated neurocognitive disorders. 2015; 10(2):136-43.
5. Cantres-Rosario YM, Hernandez N, Negron K, Perez-Laspiur J, Leszyk J, Shaffer SA, Meléndez LM. . J Virol Antivir Res. Interacting partners of macrophage-secreted cathepsin B contribute to HIV-induced neuronal apoptosis. 2015; 29(16):2081-92.
6. Colón K, Vázquez-Santiago F, Rivera-Amill V, Delgado G, Massey SE, Wojna V, Noel RJ Jr, Meléndez LM. J Virol Antivir Res. HIV gp120 sequence variability associated with HAND in Hispanic Women. 2015; 4(3):143.
7. Vázquez-Santiago F, García Y, Rivera-Román I, Noel RJ Jr, Wojna V, Meléndez LM, Rivera-Amill V. . J Virol Antivir Res. Longitudinal Analysis of Cerebrospinal Fluid and Plasma HIV-1 Envelope Sequences Isolated From a Single Donor with HIV Asymptomatic Neurocognitive Impairment. 2015; 4(1).
8. Zenón F, Cantres-Rosario Y, Adiga R, Gonzalez M, Rodriguez-Franco E, Langford D, Melendez LM. . J Neurovirol. HIV-infected microglia mediate cathepsin B-induced neurotoxicity. 2015; 21(5):544-58.
9. Zenon F, Segarra A, Gonzalez M, and Meléndez LM*, 2014. J Neuroimmune Pharmacology. P. J Neuroimmune Pharmacology. Cocaine Potentiates Cathepsin B Secretion and Neuronal Apoptosis from in HIV-infected Macrophages. 2014; 9(5):703-15.

Reviews/Chapters/Editorials icon

 

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1. Rivera LE, Colon K, Cantres-Rosario YM, Zenon FM, Melendez LM. Curr HIV Res. Macrophage derived cystatin B/cathepsin B in HIV replication and neuropathogenesis. 2014; 12(2):111-20.