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María J. Crespo
Title Professor
Faculty Rank Professor
Degree Ph.D.
Institution University of Puerto Rico
Department Physiology
Clusters Cardiovascular and Related Diseases
UPR-Medical Sciences Campus
School of Medicine
Department of Physiology
P.O. Box 365067
City San Juan
State PR
Postal Code 00936-5067
Telephone (787) 758-2525 ext. 5078, 1913
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  My research interests are in the area of cardiovascular Physiology and Pharmacology, especially in pathophysiological conditions such as hypertension and congestive heart failure. In particular, I am interested in understanding the mechanism underlying endothelial dysfunction and the vascular modifications present in these conditions. We study alterations in the nitric oxide (NO) signal transduction pathway and in the renin-angiotensin system (RAS) using animal models of hypertension and heart failure.

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1. Román M, Ramírez JM, Morales M, Crespo MJ. Significant reduction of vascular reactivity with dantrolene and nimodipine in diabetic rats: a potential approach to cerebral vasospasm management in diabetes. Pharmacol Rep. 2020 Feb; 72(1):126-134.
2. Crespo MJ, Quidgley J. Simvastatin, atorvastatin, and pravastatin equally improve the hemodynamic status of diabetic rats. World J Diabetes. 2015 Aug 25; 6(10):1168-78.
3. Hernández-Gil de Lamadrid J, Nieves-Rivera JJ, Mora L, Corretjer L, Altieri PI, Suárez A, Banchs HL, Muñiz J, Soto MI, Escobales N, Crespo M. Metabolic Changes After Roux-N-Y Bariatric Surgery In Hispanics. Bol Asoc Med P R. 2015 Jul-Sep; 107(3):66-9.
4. Altieri PI, Marcial JM, Banchs HL, Escobales N, Crespo M, González W. Coronary levels of angiotensin-II and endothelin-I in diabetic patients with and without coronary artery disease. Bol Asoc Med P R. 2015 Jan-Mar; 107(1):5-7.
5. González W, Altieri PI, Alvarado E, Banchs HL, Colón E, Escobales N, Crespo M. Celiac trunk and branches dissection due to energy drink consumption and heavy resistance exercise: case report and review of literature. Bol Asoc Med P R. 2015 Jan-Mar; 107(1):38-40.
6. Quidgley J, Cruz N, Crespo MJ. Atorvastatin improves systolic function, but does not prevent the development of dilated cardiomyopathy in streptozotocin-induced diabetic rats. Ther Adv Cardiovasc Dis. 2014 Aug; 8(4):133-144.
7. Crespo MJ, Cruz N, Quidgley J, Torres H, Hernandez C, Casiano H, Rivera K. Daily administration of atorvastatin and simvastatin for one week improves cardiac function in type 1 diabetic rats. Pharmacology. 2014; 93(1-2):84-91.
8. Bou E, Hernández P, Cerezo L, Altieri PI, Gurrea CM, Figueroa R, García P, González-Cancel IF, Defendini E, Escobales N, Crespo M, Banchs HL. Heart tumors in Puerto Rico de novo atrial fibrillation as clinical presentation in a subgroup of patients. P R Health Sci J. 2013 Mar; 32(1):14-7.
9. González W, Altieri PI, Alvarado S, Banchs HL, Escobales N, Crespo M, Borges W. Magnesium: the forgotten electrolyte. Bol Asoc Med P R. 2013; 105(3):17-20.
10. Altieri PI, Marcial JM, Banchs H, Escobales N, Crespo M. Ethnicity and genetics are more important than diabetes mellitus and hypertension in producing cardiovascular events in patients with the metabolic syndrome: emphasis in the Puerto Rico population. Bol Asoc Med P R. 2013; 105(3):56-63.
11. Crespo MJ, Cangiano JL, Altieri PI, Escobales N. Aliskiren improves left ventricular dysfunction and reduces cardiac dilation in Syrian cardiomyopathic hamsters. J Cardiovasc Pharmacol. 2012 Jun; 59(6):547-52.
12. Altieri PI, Figueroa Y, Banchs HL, de Lamadrid JH, Escobales N, Crespo M. Higher incidence of atrial fibrillation in the metabolic syndrome: a Hispanic population study. Bol Asoc Med P R. 2011 Oct-Dec; 103(4):24-7.
13. Crespo MJ, Marrero M, Cruz N, Quidgley J, Creagh O, Torres H, Rivera K. Diabetes alters cardiovascular responses to anaesthetic induction agents in STZ-diabetic rats. Diab Vasc Dis Res. 2011 Oct; 8(4):299-302.
14. Marcial JM, Altieri PI, Banchs H, Escobales N, Crespo M. Metabolic syndrome among Puerto Ricans and other Hispanic populations. P R Health Sci J. 2011 Sep; 30(3):145-51.
15. Crespo MJ, Cruz N, Altieri PI, Escobales N. Chronic treatment with N-acetylcysteine improves cardiac function but does not prevent progression of cardiomyopathy in Syrian cardiomyopathic hamsters. J Cardiovasc Pharmacol Ther. 2011 Jun; 16(2):197-204.
16. Escobales N, Ramos JA, Santacana GE, Crespo MJ. Hemodynamic alterations in the coronary circulation of cardiomyopathic hamsters: age and Ang II-dependent mechanisms. J Card Fail. 2009 Dec; 15(10):929-38.
17. Escobales N, Crespo MJ. Early pathophysiological alterations in experimental cardiomyopathy: the Syrian cardiomyopathic hamster. P R Health Sci J. 2008 Dec; 27(4):307-14.
18. Crespo MJ, Cruz N, Altieri PI, Escobales N. Enalapril and losartan are more effective than carvedilol in preventing dilated cardiomyopathy in the Syrian cardiomyopathic hamster. J Cardiovasc Pharmacol Ther. 2008 Sep; 13(3):199-206.
19. Crespo MJ, Zalacaín J, Dunbar DC, Cruz N, Arocho L. Cardiac oxidative stress is elevated at the onset of dilated cardiomyopathy in streptozotocin-diabetic rats. J Cardiovasc Pharmacol Ther. 2008 Mar; 13(1):64-71.
20. Figueroa Y, Altieri PI, Banchs H, Hernández J, López JC, Escobales N, Crespo MJ. Syncope in Puerto Rico. Bol Asoc Med P R. 2007 Jul-Sep; 99(3):207-10.
21. Cruz N, Arocho L, Rosario L, Crespo MJ. Chronic administration of carvedilol improves cardiac function in 6-month-old Syrian cardiomyopathic hamsters. Pharmacology. 2007; 80(2-3):144-50.
22. Pariente M, Bartolomé J, Lorente S, Crespo MD. [Age distribution of serological profiles of Epstein-Barr virus infection: review of results from a diagnostic laboratory]. Enferm Infecc Microbiol Clin. 2007 Feb; 25(2):108-10.
23. Figueroa Y, Altieri PI, Banchs H, Escobales N, Crespo M, Defendini E, González-Cancel I. Coronary artery abnormalities in Puerto Rico. P R Health Sci J. 2006 Sep; 25(3):225-7.
24. Crespo MJ, Quidgley J, Dunbar DC. Differential regulation of the left and right coronary arteries of swine. Pharmacology. 2006; 77(3):137-43.
25. Crespo MJ, Altieri PI, Escobales N. Increased vascular angiotensin II binding capacity and ET-1 release in young cardiomyopathic hamsters. Vascul Pharmacol. 2006 Apr; 44(4):247-52.
26. Crespo MJ, Quidgley JA. Statins decrease serotonin-induced contractions in coronary arteries of swine in vitro. Pharmacology. 2006; 76(3):141-7.
27. Escobales N, Crespo MJ. Oxidative-nitrosative stress in hypertension. Curr Vasc Pharmacol. 2005 Jul; 3(3):231-46.
28. Guerra J, De Jesus A, Santiago-Borrero P, Roman-Franco A, Rodríguez E, Crespo MJ. Plasma nitric oxide levels used as an indicator of doxorubicin-induced cardiotoxicity in rats. Hematol J. 2005; 5(7):584-8.
29. González-Pérez J, Crespo MJ. Chronic effects of toremifene on the vasculature of menopause-induced rats. Vascul Pharmacol. 2003 Dec; 40(5):261-8.
30. González-Pérez J, Crespo MJ. Acute effects of toremifene on the vasculature of intact and menopause-induced rats. Vascul Pharmacol. 2003 Nov; 40(4):205-11.
31. Crespo MJ, Moreta S, González J. Cardiovascular deterioration in STZ-diabetic rats: possible role of vascular RAS. Pharmacology. 2003 May; 68(1):1-8.

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