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Siddharth Pratap
Title Director of Bioinformatics, Director of Proteomics
Faculty Rank Assistant Professor
Degree PhD, MS
Institution Meharry Medical College
Department Bioinformatics Core, Proteomics Core
Clusters Informatics
Dept. of Microbiology & Immunonogy
rm# 4108 West Basic Science Building
1005 D.B. Todd Blvd
City Nashville
State TN
Postal Code 37208
Telephone (615) 327-6219
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Title Assistant Professor
Institution Meharry Medical College
Department School of Graduate Sudies

Awards and Honors icon

1993 Indiana University Howard Hughes Undergraduate Research Award
1995 Cook Inc. Honorable mention for the design of novel biomedical device
2000 Woods Hole, MA Woods Hole Immuno-Parasitology 2000, Trainee Presentation Award
2008 Cadiz, KY Oak Ridge National Labs Bioinformatics Summit

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  I have the expertise in BioMedical Informatics, Proteomics and Computational Biology to successfully fulfill my role in the Meharry Clinical and Translational Research Center (MeTRC). As the director of the Meharry Microarray-Bioinformatics Core and the MeTRC Biomedical Informatics key activity, I have created a comprehensive bioinformatics analysis infrastructure at Meharry Medical College. I have also been active in launching new programs and capabilities as evidenced by my lead role in the Meharry Proteomics Core, in which I serve as the Managing Director. Additionally, I have been successful in expanding Meharry’s educational training in Translational research by initiating a new course in Bioinformatics as part of the School of Graduate Studies and Research curriculum. My experience has allowed me to have excellent multi-disciplinary, multi-institutional interactions. Together, we have effectively incorporated basic science, clinical investigation, and bioinformatics, thus allowing for a translational approach to research in health disparities. I believe that the current project is an excellent area for me to become involved as my experience fits it effectively.

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1. Walker MY, Pratap S, Southerland JH, Farmer-Dixon CM, Lakshmyya K, Gangula PR. Role of oral and gut microbiome in nitric oxide-mediated colon motility. Nitric Oxide. 2018 Feb 28; 73:81-88.
2. Matthews QL, Farrow AL, Rachakonda G, Gu L, Nde P, Krendelchtchikov A, Pratap S, Sakhare SS, Sabbaj S, Lima MF, Villalta F. Epitope Capsid-Incorporation: New Effective Approach for Vaccine Development for Chagas Disease. Pathog Immun. 2016 Fall-Winter; 1(2):214-233.
3. Xie Y, Lu W, Liu S, Yang Q, Goodwin JS, Sathyanarayana SA, Pratap S, Chen Z. MMP7 interacts with ARF in nucleus to potentiate tumor microenvironments for prostate cancer progression in vivo. Oncotarget. 2016 Jul 26; 7(30):47609-47619.
4. Udoko AN, Johnson CA, Dykan A, Rachakonda G, Villalta F, Mandape SN, Lima MF, Pratap S, Nde PN. Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruzi. PLoS Negl Trop Dis. 2016 Jan; 10(1):e0003747.
5. Addai AB, Pandhare J, Paromov V, Mantri CK, Pratap S, Dash C. Cocaine modulates HIV-1 integration in primary CD4+ T cells: implications in HIV-1 pathogenesis in drug-abusing patients. J Leukoc Biol. 2015 Apr; 97(4):779-90.
6. Mantri CK, Chen CH, Dong X, Goodwin JS, Pratap S, Paromov V, Xie H. Fimbriae-mediated outer membrane vesicle production and invasion of Porphyromonas gingivalis. Microbiologyopen. 2015 Feb; 4(1):53-65.
7. Farrow AL, Rachakonda G, Gu L, Krendelchtchikova V, Nde PN, Pratap S, Lima MF, Villalta F, Matthews QL. Immunization with Hexon modified adenoviral vectors integrated with gp83 epitope provides protection against Trypanosoma cruzi infection. PLoS Negl Trop Dis. 2014 Aug; 8(8):e3089.
8. Goode G, Pratap S, Eltom SE. Depletion of the aryl hydrocarbon receptor in MDA-MB-231 human breast cancer cells altered the expression of genes in key regulatory pathways of cancer. PLoS One. 2014; 9(6):e100103.
9. Chaudhuri S, Pratap S, Paromov V, Li Z, Mantri CK, Xie H. Identification of a diguanylate cyclase and its role in Porphyromonas gingivalis virulence. Infect Immun. 2014 Jul; 82(7):2728-35.
10. Mandape SN, Marshall DR, Dent LL, Pratap S. Draft Genome Sequence of Multidrug-Resistant Acinetobacter baumannii Strain MMC4, Isolated from a Patient in Tennessee. Genome Announc. 2014 Feb 20; 2(1).
11. Johnson CA, Rachakonda G, Kleshchenko YY, Nde PN, Madison MN, Pratap S, Cardenas TC, Taylor C, Lima MF, Villalta F. Cellular response to Trypanosoma cruzi infection induces secretion of defensin a-1, which damages the flagellum, neutralizes trypanosome motility, and inhibits infection. Infect Immun. 2013 Nov; 81(11):4139-48.
12. Pratap S, Brown LE, Izban MG, Nowicki S, Nowicki BJ. Accurate preterm labor diagnosis using a CD55-TLR4 combination biomarker model. J Biomed Sci Eng. 2013 Mar; 6:253-257.
13. Nde PN, Lima MF, Johnson CA, Pratap S, Villalta F. Regulation and use of the extracellular matrix by Trypanosoma cruzi during early infection. Front Immunol. 2012; 3:337.
14. Watson K, Koumangoye R, Thompson P, Sakwe AM, Patel T, Pratap S, Ochieng J. Fetuin-A triggers the secretion of a novel set of exosomes in detached tumor cells that mediate their adhesion and spreading. FEBS Lett. 2012 Sep 21; 586(19):3458-63.
15. Johnson CA, Kleshchenko YY, Ikejiani AO, Udoko AN, Cardenas TC, Pratap S, Duquette MA, Lima MF, Lawler J, Villalta F, Nde PN. Thrombospondin-1 interacts with Trypanosoma cruzi surface calreticulin to enhance cellular infection. PLoS One. 2012; 7(7):e40614.
16. Jules GE, Pratap S, Ramesh A, Hood DB. In utero exposure to benzo(a)pyrene predisposes offspring to cardiovascular dysfunction in later-life. Toxicology. 2012 May 16; 295(1-3):56-67.
17. Dey A, Mantri CK, Pandhare-Dash J, Liu B, Pratap S, Dash C. Downregulation of APOBEC3G by xenotropic murine leukemia-virus related virus (XMRV) in prostate cancer cells. Virol J. 2011 Dec 12; 8:531.
18. Pawelczyk E, Nowicki BJ, Izban MG, Pratap S, Sashti NA, Sanderson M, Nowicki S. Spontaneous preterm labor is associated with an increase in the proinflammatory signal transducer TLR4 receptor on maternal blood monocytes. BMC Pregnancy Childbirth. 2010 Oct 21; 10:66.
19. Dent LL, Marshall DR, Pratap S, Hulette RB. Multidrug resistant Acinetobacter baumannii: a descriptive study in a city hospital. BMC Infect Dis. 2010 Jul 07; 10:196.
20. Nde PN, Johnson CA, Pratap S, Cardenas TC, Kleshchenko YY, Furtak VA, Simmons KJ, Lima MF, Villalta F. Gene network analysis during early infection of human coronary artery smooth muscle cells by Trypanosoma cruzi and Its gp83 ligand. Chem Biodivers. 2010 May; 7(5):1051-64.
21. Cardenas TC, Johnson CA, Pratap S, Nde PN, Furtak V, Kleshchenko YY, Lima MF, Villalta F. REGULATION of the EXTRACELLULAR MATRIX INTERACTOME by Trypanosoma cruzi. Open Parasitol J. 2010; 4:72-76.
22. Nowicki S, Izban MG, Pawelczyk E, Agboto VK, Pratap S, Olson G, Nowicki B. Preterm labor: CD55 in maternal blood leukocytes. Am J Reprod Immunol. 2009 May; 61(5):360-7.
23. Ochieng J, Pratap S, Khatua AK, Sakwe AM. Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes. Exp Cell Res. 2009 Jul 01; 315(11):1875-88.
24. Augustine SA, Kleshchenko YY, Nde PN, Pratap S, Ager EA, Burns JM, Lima MF, Villalta F. Molecular cloning of a Trypanosoma cruzi cell surface casein kinase II substrate, Tc-1, involved in cellular infection. Infect Immun. 2006 Jul; 74(7):3922-9.
25. Nde PN, Simmons KJ, Kleshchenko YY, Pratap S, Lima MF, Villalta F. Silencing of the laminin gamma-1 gene blocks Trypanosoma cruzi infection. Infect Immun. 2006 Mar; 74(3):1643-8.
26. Boczko EM, Cooper TG, Gedeon T, Mischaikow K, Murdock DG, Pratap S, Wells KS. Structure theorems and the dynamics of nitrogen catabolite repression in yeast. Proc Natl Acad Sci U S A. 2005 Apr 19; 102(16):5647-52.
27. Villalta F, Zhang Y, Bibb KE, Pratap S, Burns JM, Lima MF. Signal transduction in human macrophages by gp83 ligand of Trypanosoma cruzi: trypomastigote gp83 ligand up-regulates trypanosome entry through protein kinase C activation. Mol Cell Biol Res Commun. 1999 Jul; 2(1):64-70.

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