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Richard Yanagihara
Title Director, Research Coordinating Center
Faculty Rank Professor
Degree M.D., M.P.H.
Institution University of Hawaii
Department Department of Pediatrics
Clusters Infectious and Immunological Diseases
Address
John A. Burns School of Medicine
University of Hawaii at Manoa
651 Ilalo Street, BSB320L
City Honolulu
State HI
Postal Code 96813
Telephone (808) 692-1610
Fax (808) 692-1976
Email
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Other Positions icon

Title Professor
Institution John A. Burns School of Medicine
Department Tropical Medicine, Medical Microbiology and Pharmacology

Awards and Honors icon

1990 National Institutes of Health Outstanding Service Medal, U.S. Public Health Service
1991 National Institutes of Health Bailey K. Ashford Medal, American Society of Tropical Medicine and Hygiene
1993 National Institutes of Health Meritorious Service Medal, U.S. Public Health Service
1993 National Institute of Infectious Diseases Senior Fellow, Japan Society for the Promotion of Science
2001 Hokkaido University School of Medicine Senior Fellow, Japan Society for the Promotion of Science
2013 International Society for Hantavirology Joel M. Dalrymple Memorial Award
2013 Korea University College of Medicine Visiting Professorship
2013 Medical University of Lódz Visiting Professorship
2014 RCMI Program Directors' Association Frederick C. Greenwood Award
2014 National Institute of Infectious Diseases Senior Fellow, Japan Society for the Promotion of Science
2016 Medical University of Lódz Visiting Professorship
2017 Achievement Rewards for College Scientists Foundation Scientist of the Year

Narrative icon

  Dr. Richard Yanagihara, formerly a tenured intramural NIH investigator, was recruited through an interagency personnel agreement in 1995 to assist in building capacity for a laboratory-based retrovirology research program in the Research Centers in Minority Institutions (RCMI) program at the University of Hawai‘i at Manoa. He has served as the RCMI Program Director from 2000-2011, and has been the principal investigator of the Pacific Center for Emerging Infectious Diseases Research since 2003, and the director of the Research Core for the RCMI Translational Research Network since 2008. As such, he has played a critical role in coordinating the development of much-needed infrastructure for bioscience research at the university and across the RCMI community. In particular, he has been deeply involved in mentoring junior faculty, as well as developing programs that provide grant support for pilot projects and bridging funds. His extensive knowledge about the biomedical research portfolio and research resources at the 18 RCMI grantee institutions, as well as his long-standing personal relationships with RCMI investigators, makes him eminently qualified to take a leadership role in the RTRN Research Coordinating Center.

Dr. Yanagihara's own research has been conducted largely in the context of exploiting naturally occurring paradigms of high-incidence ‘place diseases’ in populations isolated by virtue of genetics, culture and/or geography. Notable among these scientific explorations, chronicled in nearly 300 publications, have been the demonstration of a cohort effect in the high-incidence focus of amyotrophic lateral sclerosis and parkinsonism-dementia among Chamorros on Guam and the discovery and characterization of genetically distinct variants of human T-cell lymphotropic virus type I in remote Melanesian populations in Papua New Guinea and Solomon Islands. In addition, his decades-long research effort on the molecular phylogeny and phylogeography of rodent-borne hantaviruses has led to the realization that shrews and moles (Order Eulipotyphla) and insectivorous bats (Order Chiroptera) may have served as the original reservoirs of ancestral hantaviruses. New knowledge and insights from this research will help to rewrite textbook chapters on hantaviruses.

Programs, Membership, and Biomedical Research icon

RTRN Member - Senior Management
RTRN Member - Steering Committee

NIH Awarded Grants icon

  Research projects funded by the National Institutes of Health (NIH), the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Department of Veterans Affairs (VA)

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1.
2017Pacific Center for Emerging Infectious Diseases Research5P30GM114737-03
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2017Administrative and Mentoring Core5P30GM114737-03
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2017Small Grants Program5P30GM114737-03
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2016Administrative and Mentoring Core5P30GM114737-02
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2016Pacific Center for Emerging Infectious Diseases Research3P30GM114737-02S1
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2016Pacific Center for Emerging Infectious Diseases Research5P30GM114737-02
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2016Small Grants Program5P30GM114737-02
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2015Small Grants Program1P30GM114737-01
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2015Pacific Center for Emerging Infectious Diseases Research1P30GM114737-01
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2015Administrative and Mentoring Core1P30GM114737-01
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2014Pacific Center for Emerging Infectious Diseases Research5P20GM103516-10
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2013Pacific Center for Emerging Infectious Diseases Research5P20GM103516-09
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2012Pacific Center for Emerging Infectious Diseases Research8P20GM103516-08
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2011Pacific Center for Emerging Infectious Diseases Research5P20RR018727-07
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2011Intraspecies Transmission and Infectivity of Insectivore-Borne Hantaviruses5R01AI075057-04
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2011ADMINISTRATIVE &MENTORING CORE5P20RR018727-07
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2010Pacific Center for Emerging Infectious Diseases Research2P20RR018727-06A1
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2010Intraspecies Transmission and Infectivity of Insectivore-Borne Hantaviruses5R01AI075057-03
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2010U HAWAII COBRE: ADMINISTRATIVE &MENTORING CORE2P20RR018727-06A1
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2009Intraspecies Transmission and Infectivity of Insectivore-Borne Hantaviruses5R01AI075057-02
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2008Intraspecies Transmission and Infectivity of Insectivore-Borne Hantaviruses1R01AI075057-01A1
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2007U HAWAII COBRE: ADMINISTRATIVE &MENTORING CORE5P20RR018727-05
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2007Pacific Center for Emerging Infectious Diseases Research5P20RR018727-05
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2006U HAWAII COBRE: ADMINISTRATIVE &MENTORING CORE5P20RR018727-04
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2006Pacific Center for Emerging Infectious Diseases Research5P20RR018727-04
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2005Pacific Center for Emerging Infectious Diseases Research5P20RR018727-03
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2005U HAWAII COBRE: ADMINISTRATIVE &MENTORING CORE5P20RR018727-03
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2004Pacific Center for Emerging Infectious Diseases Research5P20RR018727-02
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2004SUPPLEMENT FOR EQUIPMENT FOR AIDS RESEARCH5G12RR003061-19
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2003Pacific Center for Emerging Infectious Diseases Research1P20RR018727-01
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2002A3: HUMAN RETROVIRUSES &OTHER EMERGING PATHOGENS IN HAWAII: AIDS CORE5G12RR003061-17
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2002A3C: PATHOGENESIS OF AIDS &HIV 1 ASSOC DIS &OPPORTUNISTIC INFECTIONS: TUMOR3G12RR003061-17S1
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2002A3D: ETIOLOGY &PATHOGENESIS OF NEW &EMERGING INFECTIOUS DISEASES: KAWASAKI DIS5G12RR003061-17
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2002A3: HUMAN RETROVIRUSES &OTHER EMERGING PATHOGENS IN HAWAII: AIDS CORE3G12RR003061-17S1
35.
2002A3C: PATHOGENESIS OF AIDS &HIV 1 ASSOC DIS &OPPORTUNISTIC INFECTIONS: TUMOR5G12RR003061-17
36.
2002A3D: ETIOLOGY &PATHOGENESIS OF NEW &EMERGING INFECTIOUS DISEASES: KAWASAKI DIS3G12RR003061-17S1
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2000A3: HUMAN RETROVIRUSES &OTHER EMERGING PATHOGENS IN HAWAII: AIDS CORE5G12RR003061-15
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2000A3D: ETIOLOGY &PATHOGENESIS OF NEW &EMERGING INFECTIOUS DISEASES: KAWASAKI DIS5G12RR003061-15
39.
2000A3C: PATHOGENESIS OF AIDS &HIV 1 ASSOC DIS &OPPORTUNISTIC INFECTIONS: TUMOR5G12RR003061-15
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1999A3: HUMAN RETROVIRUSES &OTHER EMERGING PATHOGENS IN HAWAII: AIDS CORE5G12RR003061-14
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1999A3D: ETIOLOGY &PATHOGENESIS OF NEW &EMERGING INFECTIOUS DISEASES: KAWASAKI DIS5G12RR003061-14
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1999A3C: PATHOGENESIS OF AIDS &HIV 1 ASSOC DIS &OPPORTUNISTIC INFECTIONS: TUMOR5G12RR003061-14
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1998AIDS CORE: CLINICAL RETROVIROL: RETROVIRUSES &OTHER EMERGING PATHOGEN IN HAWAII5G12RR003061-13
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1998ETIOLOGY &PATHOGENESIS OF NEW &EMERGING INFECTIOUS DISEASES5G12RR003061-13
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1998PATHOGENESIS OF AIDS &HIV 1 ASSOC DISEASES &OPPT INFECTIONS5G12RR003061-13
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1997PATHOGENESIS OF AIDS &HIV 1 ASSOC DISEASES &OPPT INFECTIONS5G12RR003061-12
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1997AIDS CORE: HUMAN RETROVIRUSES &OTHER EMERGING PATHOGENS IN HAWAII5G12RR003061-12
48.
1997ETIOLOGY &PATHOGENESIS OF NEW &EMERGING INFECTIOUS DISEASES: HIV5G12RR003061-12
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1996INFRASTRUCTURE DEVELOPMENT FOR HIV CLINICAL RESEARCH2G12RR003061-11
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1996SURVEILLANCE OF HIV1 INFECTION IN MELANESIA &SOUTHEAST ASIA2G12RR003061-11
51.
1996HUMAN RETROVIRUSES--CLINICAL &MOLECULAR RETROVIROLOGY2G12RR003061-11
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1996HIV1 &HIV1 &II COINFECTION--SEROPREVALENCE &NATURAL HISTORY2G12RR003061-11
53.
1996PREVALENCE OF DISEASE ASSOCIATED WITH HTLV1 P40 TAX GENE M2G12RR003061-11

Publications icon

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1. Laenen L, Vergote V, Kafetzopoulou LE, Wawina TB, Vassou D, Cook JA, Hugot JP, Deboutte W, Kang HJ, Witkowski PT, Köppen-Rung P, Krüger DH, Licková M, Stang A, Striešková L, Szemeš T, Markowski J, Hejduk J, Kafetzopoulos D, Van Ranst M, Yanagihara R, Klempa B, Maes P. A Novel Hantavirus of the European Mole, Bruges Virus, Is Involved in Frequent Nova Virus Coinfections. Genome Biol Evol. 2018 Jan 01; 10(1):45-55.
2. Dunnum JL, Yanagihara R, Johnson KM, Armien B, Batsaikhan N, Morgan L, Cook JA. Biospecimen Repositories and Integrated Databases as Critical Infrastructure for Pathogen Discovery and Pathobiology Research. PLoS Negl Trop Dis. 2017 01; 11(1):e0005133.
3. Yanagihara R, Nerurkar VR, Hui G, Jacobs GA. Medical School Hotline: Pacific Center for Emerging Infectious Diseases Research. Hawaii J Med Public Health. 2017 01; 76(1):23-26.
4. Arai S, Taniguchi S, Aoki K, Yoshikawa Y, Kyuwa S, Tanaka-Taya K, Masangkay JS, Omatsu T, Puentespina R, Watanabe S, Alviola P, Alvarez J, Eres E, Cosico E, Quibod MNRM, Morikawa S, Yanagihara R, Oishi K. Molecular phylogeny of a genetically divergent hantavirus harbored by the Geoffroy's rousette (Rousettus amplexicaudatus), a frugivorous bat species in the Philippines. Infect Genet Evol. 2016 11; 45:26-32.
5. Kang HJ, Gu SH, Cook JA, Yanagihara R. Dahonggou Creek virus, a divergent lineage of hantavirus harbored by the long-tailed mole (Scaptonyx fusicaudus). Trop Med Health. 2016; 44:16.
6. Arai S, Kang HJ, Gu SH, Ohdachi SD, Cook JA, Yashina LN, Tanaka-Taya K, Abramov SA, Morikawa S, Okabe N, Oishi K, Yanagihara R. Genetic Diversity of Artybash Virus in the Laxmann's Shrew (Sorex caecutiens). Vector Borne Zoonotic Dis. 2016 07; 16(7):468-75.
7. Gu SH, Arai S, Yu HT, Lim BK, Kang HJ, Yanagihara R. Genetic variants of Cao Bang hantavirus in the Chinese mole shrew (Anourosorex squamipes) and Taiwanese mole shrew (Anourosorex yamashinai). Infect Genet Evol. 2016 06; 40:113-118.
8. Gu SH, Kumar M, Sikorska B, Hejduk J, Markowski J, Markowski M, Liberski PP, Yanagihara R. Isolation and partial characterization of a highly divergent lineage of hantavirus from the European mole (Talpa europaea). Sci Rep. 2016 Feb 19; 6:21119.
9. Tsunoda I, Omura S, Sato F, Kusunoki S, Fujita M, Park AM, Hasanovic F, Yanagihara R, Nagata S. Neuropathogenesis of Zika Virus Infection : Potential Roles of Antibody-Mediated Pathology. Acta Med Kinki Univ. 2016; 41(2):37-52.
10. Gu SH, Kim YS, Baek LJ, Kurata T, Yanagihara R, Song JW. Lethal disease in infant and juvenile Syrian hamsters experimentally infected with Imjin virus, a newfound crocidurine shrew-borne hantavirus. Infect Genet Evol. 2015 Dec; 36:231-239.
11. Gu SH, Hejduk J, Markowski J, Markowski M, Liberski PP, Yanagihara R. Whole-Genome Sequence of a Novel Hantavirus Isolated from the European Mole (Talpa europaea). Genome Announc. 2015 May 28; 3(3).
12. Yashina LN, Abramov SA, Dupal TA, Danchinova GA, Malyshev BS, Hay J, Gu SH, Yanagihara R. Hokkaido genotype of Puumala virus in the grey red-backed vole (Myodes rufocanus) and northern red-backed vole (Myodes rutilus) in Siberia. Infect Genet Evol. 2015 Jul; 33:304-13.
13. Gu SH, Hejduk J, Markowski J, Kang HJ, Markowski M, Polatynska M, Sikorska B, Liberski PP, Yanagihara R. Co-circulation of soricid- and talpid-borne hantaviruses in Poland. Infect Genet Evol. 2014 Dec; 28:296-303.
14. Shin OS, Song GS, Kumar M, Yanagihara R, Lee HW, Song JW. Hantaviruses induce antiviral and pro-inflammatory innate immune responses in astrocytic cells and the brain. Viral Immunol. 2014 Aug; 27(6):256-66.
15. Bennett SN, Gu SH, Kang HJ, Arai S, Yanagihara R. Reconstructing the evolutionary origins and phylogeography of hantaviruses. Trends Microbiol. 2014 Aug; 22(8):473-82.
16. Gu SH, Lim BK, Kadjo B, Arai S, Kim JA, Nicolas V, Lalis A, Denys C, Cook JA, Dominguez SR, Holmes KV, Urushadze L, Sidamonidze K, Putkaradze D, Kuzmin IV, Kosoy MY, Song JW, Yanagihara R. Molecular phylogeny of hantaviruses harbored by insectivorous bats in Côte d'Ivoire and Vietnam. Viruses. 2014 Apr 29; 6(5):1897-910.
17. Kang HJ, Stanley WT, Esselstyn JA, Gu SH, Yanagihara R. Expanded host diversity and geographic distribution of hantaviruses in sub-Saharan Africa. J Virol. 2014 Jul; 88(13):7663-7.
18. Lee JG, Gu SH, Baek LJ, Shin OS, Park KS, Kim HC, Klein TA, Yanagihara R, Song JW. Muju virus, harbored by Myodes regulus in Korea, might represent a genetic variant of Puumala virus, the prototype arvicolid rodent-borne hantavirus. Viruses. 2014 Apr 14; 6(4):1701-14.
19. Lee JG, Gu SH, Baek LJ, Shin OS, Kim HC, Klein TA, Yanagihara R, Song JW. Whole-genome sequence of muju virus, an arvicolid rodent-borne hantavirus. Genome Announc. 2014 Feb 27; 2(1).
20. Kaufusi PH, Kelley JF, Yanagihara R, Nerurkar VR. Induction of endoplasmic reticulum-derived replication-competent membrane structures by West Nile virus non-structural protein 4B. PLoS One. 2014; 9(1):e84040.
21. Yanagihara R, Gu SH, Arai S, Kang HJ, Song JW. Hantaviruses: rediscovery and new beginnings. Virus Res. 2014 Jul 17; 187:6-14.
22. Hugot JP, Gu SH, Feliu C, Ventur J, Ribas A, Dormion J, Yanagihara R, Nicolas V. Genetic Diversity of Talpa Europaea and Nova Hanta Virus (NVAV) in France. Bull Acad Vet Fr. 2014; 167(3).